봉크렉산
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봉크렉산 속성
- 녹는점
- 50-60°
- 알파
- D25 +162.5°
- 끓는 점
- 715.1±60.0 °C(Predicted)
- 밀도
- 1.114±0.06 g/cm3(Predicted)
- 저장 조건
- -20°C
- 용해도
- DMSO(최대 100mg/ml) 또는 물(최대 1mg/ml)에 용해됩니다.
- 물리적 상태
- 동결건조된 고체
- 산도 계수 (pKa)
- 4.15±0.10(Predicted)
- 안정성
- 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 증류수 용액은 -20°에서 최대 3개월 동안 보관할 수 있습니다.
안전
WGK 독일 | - | ||
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유해 물질 데이터 | 11076-19-0(Hazardous Substances Data) | ||
독성 | LD50 i.v. in mice: 1.41 mg/kg (Lijmbach) |
봉크렉산 C화학적 특성, 용도, 생산
용도
Bongkrekic acid solution has been used as an adenine nucleotide translocator (ANT) inhibitor to find out a different approach for the inhibition of oxidative phosphorylation in intact T98G cells. It has also been used as an inhibitor of the permeabilization transition pore complex (PTPC) pore and a tool to explore the role of PTPC in induction of apoptosis.정의
ChEBI: A tricarboxylic acid that is docosa-2,4,8,10,14,18,20-heptaenedioic acid substituted at positions 2 ,5 and 17 by methyl groups, at positions 6 by a methoxy group and at position 20 by a carboxymethyl group.효소 저해제
This toxic tricarboxylic acid (FWfree-acid = 486.61 g/mol; CAS 11076-19-0), produced Pseudomonas cocovenenans, is a potent competitive inhibitor of the mitochondrial ATP-ADP translocator, effectively blocking nucleotide binding to the carrier. The name is derived from bongkrek, a moldy coconut product produced in Indonesia. The toxin accumulates when P. cocovenenans outgrows the mold. Klingenberg et al. investigated bongkrekate binding to mitochondrial membrane to examine the reorienting site mechanism. The inferred mode of inhibition requires bongkrekate to bind to the single carrier site only from the inner face of the mitochondrial membrane (i.e., the matrix side)). They confirmed the pH-dependent accumulation of [3H]bongkrekate inside the mitochondria which superimposes onto the binding at carrier sites. By breaking the membrane with Lubrol or sonication, binding to the carrier sites could be titrated, and a Kd value of approximately 5 x 10–8 M was determined. The presence of ADP or ATP increases the amount of binding but does not alter the Kd. [35S]Atractylate is displaced by [3H]bongkrekate at a 1:1 molar ratio; this displacement is dependent on ADP concentration with the Km = 0.5 x 10–6 M. See also Atractyloside The isomer known as isobongkrekic acid, which has a cis-double bond at the dicarboxylic acid end of the molecule, has similar biological activity. Target(s): Adenine nucleotide translocator, ADP/ATP carrier; ATPase; bromelain, stem; papain; ficain, or ficin.봉크렉산 준비 용품 및 원자재
원자재
준비 용품
봉크렉산 공급 업체
글로벌( 49)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32686 | 60 |
BOC Sciences | 16314854226; +16314854226 |
inquiry@bocsci.com | United States | 19743 | 58 |
Aladdin Scientific | +1-833-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
Qingdao IniKem BioPharmaTech Co.,Ltd | 0532-58268780 18653202088 |
sales@inikem.com | China | 294 | 55 |
Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 |
sj_scrc@sinopharm.com | China | 9823 | 79 |
Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 |
isunpharm@qq.com | China | 4428 | 55 |
ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 |
sales@chem-strong.com | China | 17993 | 56 |
Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51471 | 80 |
Alta Scientific Co., Ltd. | 022-6537-8550 15522853686 |
sales@altasci.com.cn | China | 4515 | 55 |
Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-0755-85201366 18938635012 |
sales@regentsciences.com | China | 9293 | 58 |
봉크렉산 관련 검색:
SACCHAROMYCES
HybriScanD Lactobac
3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
COENZYME Q2
7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE
Melatonine
CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE
DECYLUBIQUINONE
FCCP
Starch
Mesaconitine
BONGKREKIC ACID, TRIAMMONIUM SALT
Lactobacillus
NONACTIN
Vanillylidenacetone
STAPHYLOCOCCUS AUREUS CRUDE CELL SUSPENS
Monascus sp.
BONGKREKIC ACID