5-Fluoroorotic acid manufacturers and suppliers

5-Fluoroorotic acid suppliers

Properties

Melting point:: 278 °C (dec.)(lit.)

Boiling point:: 143°C (rough estimate)

Density: 1.6154 (estimate)

storage temp.: Sealed in dry,Store in freezer, under -20°C

solubility: NH₄OH 4 M: 50 mg/mL, clear, faintly yellow

pka: 2.04±0.20(Predicted)

form: solid

color: Pale yellow

Merck: 14,4176

InChIKey: LODRRYMGPWQCTR-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H335

Precautionary statements: P264-P270-P301+P312+P330-P501-P261-P305+P351+P338

Hazard Codes: Xn,Xi

Risk Statements: 22-36/37/38

Safety Statements: 26-36-36/37/39-27

WGK Germany: 3

RTECS: UV7800000

F: 10

HazardClass: IRRITANT

HS Code: 29335990

Use

5-FOA(5-Fluoroorotic acid ) has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in malarial parasites. The combination of 5-FOA and uracil has been effective in treating mice infected with Plasmodium yoelli. 5-FOA may also have potential in the treatment of human malarial infections when used in combination with other agents.

You can find 5-Fluoroorotic acid suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.