Lorazepam suppliers
Lorazepam
- CAS:
- 846-49-1
- MF:
- C15H10Cl2N2O2
- MW:
- 321.16
Company Type
Properties
- Melting point:
- 166-168°C
- Boiling point:
- 533.8±50.0 °C(Predicted)
- Density
- 1.4835 (rough estimate)
- refractive index
- 1.6070 (estimate)
- Flash point:
- 11 °C
- storage temp.
- −20°C
- solubility
- Practically insoluble in water, sparingly soluble in ethanol (96 per cent), sparingly soluble or slightly soluble in methylene chloride.
- pka
- pK1 1.3; pK2 11.5(at 25℃)
- Water Solubility
- 54mg/L(temperature not stated)
- BCS Class
- 1
- Stability:
- hygroscopic
Safety Information
- Symbol(GHS)
GHS08
- Signal word
- Warning
- Hazard statements
- H361
- Precautionary statements
- P201-P202-P280-P308+P313-P405-P501
- Hazard Codes
- Xn,T,F
- Risk Statements
- 63-39/23/24/25-23/24/25-11-36-20/21/22
- Safety Statements
- 36/37-45-16
- RIDADR
- UN 1230 3/PG 2
- WGK Germany
- 3
- RTECS
- DF0350000
- HS Code
- 2933910000
- Toxicity
- LD50 in mice, rats (mg/kg): 3178, >5000 orally (Owen)
Use
Lorazepam, 7-chloro-5-(2-chlorophenyl)-3-dihydro-3-hydroxy-2H-1,4-benzodiazepine-2-one(Ativan), is the 2'-chloro derivative of oxazepam. In keepingwith overall SARs, the 2'-chloro substituent increases activity.As with oxazepam, metabolism is relatively rapid anduncomplicated because of the 3-hydroxyl group in the compound.Thus, it also has short half-life (2–6 hours) and similarpharmacological activity.
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