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Ferulic Acid

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Products Intro: Product Name:Ferulic Acid
CAS:1135-24-6
Purity:99% HPLC
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CAS:1135-24-6
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Products Intro: Product Name:4-Hydroxy-3-methoxycinnamic acid
CAS:1135-24-6
Purity:98% Package:1MG
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Products Intro: Product Name:Ferulic acid
CAS:1135-24-6
Purity:99% Package:100G,25G,5G
Ferulic Acid Basic information
Plant sources Physical and Chemical Properties Lipid-Lowering effect Antimicrobial effect Food Industry Applications Pharmacological effects Synthetic method Uses
Product Name:Ferulic Acid
Synonyms:AKOS BBS-00006472;3-METHOXY-4-HYDROXYCINNAMIC ACID;4-HYDROXY-3-METHOXYCINNAMIC ACID;3-(4-HYDROXY-3-METHOXYPHENYL)ACRYLIC ACID;(2E)-3-(4-HYDROXY-3-METHOXYPHENYL)ACRYLIC ACID;AURORA 17401;BUTTPARK 121\04-54;(E)-3-(4-HYDROXY-3-METHOXY-PHENYL)-ACRYLIC ACID
CAS:1135-24-6
MF:C10H10O4
MW:194.18
EINECS:208-679-7
Product Categories:FINE Chemical & INTERMEDIATES;Aromatic Cinnamic Acids, Esters and Derivatives;Aromatics;Herb extract;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Inhibitors
Mol File:1135-24-6.mol
Ferulic Acid Structure
Ferulic Acid Chemical Properties
mp 168-172 °C(lit.)
storage temp. -20°C Freezer
form powder
color slightly yellow
Water Solubility soluble
CAS DataBase Reference1135-24-6(CAS DataBase Reference)
NIST Chemistry ReferenceCinnamic acid, 4-hydroxy-3-methoxy-(1135-24-6)
EPA Substance Registry System2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)- (1135-24-6)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39
WGK Germany 3
RTECS UD3365500
Hazard Note Irritant
HazardClass IRRITANT
Hazardous Substances Data1135-24-6(Hazardous Substances Data)
MSDS Information
ProviderLanguage
3-(4-Hydroxy-3-methoxyphenyl)acrylic acid English
SigmaAldrich English
ACROS English
ALFA English
Ferulic Acid Usage And Synthesis
Plant sourcesFerulic acid is a kind of phenolic acid extracted from the resin of ferula asafetida. Ferula asafetida is a kind of Umbelliferae perennial herb with a strong garlic smell and living in sandy areas. It is mainly produced in Xinjiang. During the nascent stage, there are only root leaves. At 5 years, scape emerges. The scape is very strong with its height being up to two meters. At end spring and early summer (flowering stage to early fruit stage), apply slanting cut from the upper position down to the bottom separately, collect oozing milky resin, dry it. Ferula asafetida contains volatile oils, gums and resins with oil containing various kinds of organic acids such as (R) - sec-butyl-1-propenyl disulfide, 1(1-methylthio-propyl) 1-propenyl disulfide, sec-butyl 3-methylthio-allyl-disulfide. Resin containing ferulic acid and its related esters.
 Resina Ferulae
Figure 1 is Resina Ferulae
Physical and Chemical PropertiesFerulic acid is an aromatic acid widely being presented in plant kingdom and is the components of suberin. It amount is very small presented in plants in its free state but with its main form in forming bound state with oligosaccharides, polyamines, lipids and polysaccharides. It has many health functions, such as free radical scavenging, anti-thrombotic, anti-inflammatory, anti-tumor, prevention and treatment of hypertension, heart disease, and enhanced sperm activity and so on. Ferulic acid has a low toxicity and is easy for being metabolized by human. It can be used as a food preservative and has a wide range of applications in the field of food and medication.
The above information is edited by the chemicalbook of Yan Yanyong.
Lipid-Lowering effectFerulic acid can competitively inhibit the liver mevalonate-5-pyrophosphate dehydrogenase activity, inhibiting the synthesis of cholesterol in the liver, so as to achieve the purpose of lowering blood pressure.
Antimicrobial effectFerulic acid exhibits a broader anti-bacterial spectrum. It has been found that ferulic acid is able to inhibit pathogenic bacteria such as Shigella sonnei, Klebsiella pneumoniae, Enterobacter, Escherichia coli, Citrobacter, Pseudomonas aeruginosa and 11 kinds of microorganisms which causing food corruption.
Food Industry ApplicationsIn addition to its wide application in medicine, ferulic acid has been approved by some countries to be as a food additive. Japan has approved it to be used in food antioxidants while the United States and some European countries have allowed for adopting some kinds of herbs, coffee, beans with relative high amount of ferulic acid for being antioxidant. Ferulic acid, in the food industry, is mainly used for the preparation of natural vanillin, antioxidants, preservatives, cross-linkers and functional promoting agent. The information is edited by Xiaonan from Chemicalbook.
Pharmacological effectsFerulic acid has various effects of inhibiting platelet aggregation, expectorant, and inhibition of Mycobacterium tuberculosis and so on. Clinically ferulic acid is mainly applied to the adjuvant treatment of various kinds of vascular diseases such as atherosclerosis, coronary heart disease, cerebrovascular, renal disease, pulmonary hypertension, diabetic vascular disease, and vasculitis as well as neutropenia and thrombocytopenia. It can be used for treating migraine and vascular headache. As a leukocyte-enhancement drug, this drug also has enhanced hematopoietic function. Therefore, ferulic acid may also be for the treatment of leukopenia and thrombocytopenia.
Reference: Xu Jingfeng, Yang Ming (editor) Handbook of clinical prescription drugs. Nanjing: Jiangsu Science and Technology Press .2009 on page 561.
Synthetic methodFerulic acid can be obtained through chemical synthesis and extraction. Laboratory dissolves the vanillin, malonic acid and piperidine in pyridine for reaction of three weeks after which with hydrochloric acid precipitation, you can obtain ferulic acid.
 laboratory synthesis roadmap of ferulic acid
Figure 2 laboratory synthesis roadmap of ferulic acid
UsesIt can be used as a food preservative and a kind of organic chemicals.
It can be used as the intermediates of cinametic acid. It can also be used as food preservative.
It can also be applied to biochemical studies
Chemical PropertiesPale Yellow Solid
Usageantineoplastic, choleretic, food preservative
Usageanti-oxidant, anti-inflammatory, sunscreen enhancer
UsageWidely distributed in small amounts in plants. Used as an antioxidant and food preservative
Ferulic Acid Preparation Products And Raw materials
Raw materials2,3-DICHLORO-5,8-DIHYDROXY-1,4-NAPHTHOQUINONE
Tag:Ferulic Acid(1135-24-6) Related Product Information
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