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| | PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE Basic information |
| | PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE Chemical Properties |
| Melting point | 246-248 °C (dec.)(lit.) | | storage temp. | Store at -20°C | | solubility | DMSO: 1.4 mg/ml; PBS (pH 7.2): 0.2 mg/ml | | form | A crystalline solid | | BRN | 131631 |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 |
| | PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE Usage And Synthesis |
| Description | 2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as α-ketoglutarate) and chelates zinc, thus affecting a range of enzymes. As a 2-OG mimic, it blocks the activity of 2-OG oxygenases, which include certain lysine demethylases and a variety of hydroxylases (e.g., prolyl, collagen, lysyl). 2,4-PDCA inhibits several Jumonji domain-containing lysine demethylases when used at low micromolar concentrations. Through its effects on hydroxylases, including prolyl hydroxlase 1 (IC50 = 1.5 μM), 2,4-PDCA modulates hypoxia-inducible factor turnover, collagen synthesis, and plant cell wall formation. It can inhibit zinc-dependent enzymes, like metallo-β-lactamase. 2,4-PDCA also affects and is translocated by organic anion transporters. |
| | PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE Preparation Products And Raw materials |
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