- 8-Gingerol
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- $48.00 / 1mg
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2025-04-28
- CAS:23513-08-8
- Min. Order:
- Purity: 99.92%
- Supply Ability: 10g
- 8-Gingerol
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- $0.00 / 25kg
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2024-03-28
- CAS:23513-08-8
- Min. Order: 25kg
- Purity: 1%（Water Soluble） 5%
- Supply Ability: Inquiry
- 8-Gingerol
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- $0.00 / 20mg
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2023-02-24
- CAS:23513-08-8
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
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| | 8-GINGEROL Basic information |
| Product Name: | 8-GINGEROL | | Synonyms: | GINGEROL [8];(5S)-1-(3-Methoxy-4-hydroxyphenyl)-5-hydroxydodecane-3-one;(S)-10-Oxo-12-(3-methoxy-4-hydroxyphenyl)dodecane-8-ol;8-Gingerol ,98%;(5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)dodecan-3-one;(s)-(+)-3-dodecanon;(s)-(+)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-dodecanone;5-HYDROXY-1-(4-HYDROXY-3-METHOXYPHENYL)-3-DODECANONE | | CAS: | 23513-08-8 | | MF: | C19H30O4 | | MW: | 322.44 | | EINECS: | | | Product Categories: | Miscellaneous Natural Products | | Mol File: | 23513-08-8.mol |  |
| | 8-GINGEROL Chemical Properties |
| Boiling point | 476.4±35.0 °C(Predicted) | | density | 1.058±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,2-8°C | | solubility | methanol: soluble1mg/mL, clear, colorless | | form | powder | | pka | 10.02±0.20(Predicted) | | color | white to light yellow | | Water Solubility | practically insoluble in water | | BRN | 2059802 | | InChIKey | BCIWKKMTBRYQJU-INIZCTEOSA-N | | LogP | 3.881 (est) |
| Hazard Codes | Xi | | Risk Statements | 43 | | Safety Statements | 36/37 | | WGK Germany | 3 | | RTECS | JR4362000 | | HS Code | 29145019 |
| | 8-GINGEROL Usage And Synthesis |
| Uses | 8-Gingerol has been observed to exhibit anti-oxidant behaviour towards lipids and is effective in suppressing obesity and adipose tissue inflammation. | | Definition | ChEBI: (8)-Gingerol is a beta-hydroxy ketone, a member of phenols and a monomethoxybenzene. | | Biological Activity | [8]-Gingerol is a bioactive compound found in ginger (Zingiber officinale) with anti-inflammatory and antioxidant activity. | | in vivo | 8-Gingerol (50, 100 mg/kg, i.p., once daily for 7 days) can suppress the humoral and cellular immune responses in mice, likely by directly inhibiting activated T cells and B cells[4].
8-Gingerol (10, 20 mg/kg, i.p., once daily for 14 days) improves ISO-induced myocardial fibrosis in mice by regulating the PI3K/Akt/mTOR signaling pathway, inhibiting oxidative stress, apoptosis, and autophagy[5]. | Animal Model: | OVA-immunized mice (BALB/c male mice, 5 weeks old, 18-22g, immunized with ovalbumin (OVA))[4] | | Dosage: | 25, 50, 100 mg/kg | | Administration: | Intraperitoneal injection (i.p.), once daily for 7 consecutive days | | Result: | Significantly suppressed LPS-, ConA-, and OVA-induced splenocyte proliferation in OVA-immunized mice and significantly reduced the percentage of CD19+ B cells and CD3+ T cells at high doses (50, 100 mg/kg) |
| Animal Model: | Isoproterenol (ISO)-induced myocardial fibrosis (MF) mouse model, Kunming mice (male, 6-8 weeks old, 15-20g)[5] | | Dosage: | 10 mg/kg (low dose), 20 mg/kg (high dose) | | Administration: | Intraperitoneal injection (i.p.), once daily for 14 days | | Result: | Significantly reduced the heart weight, left ventricle weight index, CK, LDH levels, ROS generation, and pathological heart damage induced by ISO. |
| | IC 50 | MMP-9; Caspase-9 |
| | 8-GINGEROL Preparation Products And Raw materials |
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