| | 2-PhenylethylaMine Basic information |
| | 2-PhenylethylaMine Chemical Properties |
| Melting point | -60 °C | | Boiling point | 197-200 °C (lit.) | | density | 0.962 g/mL at 20 °C (lit.) | | vapor density | 4.18 (vs air) | | vapor pressure | 0.4 hPa (20 °C) | | refractive index | n20/D 1.533(lit.) | | FEMA | 3220 | PHENETHYLAMINE | | Fp | 195 °F | | storage temp. | Store below +30°C. | | solubility | alcohol: freely soluble(lit.) | | pka | 9.84(at 25℃) | | form | liquid | | color | clear, colorless | | PH | 11.5 (4.3g/l, H2O, 20℃) | | Odor | fishy odor | | PH Range | 11.5 at 4.3 g/l at 20 °C | | explosive limit | 1.0-5.5%(V) | | Odor Type | fishy | | Water Solubility | SOLUBLE | | Sensitive | Air Sensitive | | JECFA Number | 1589 | | Merck | 14,6026 | | BRN | 507488 | | Stability: | Stable. Combustible. Incompatible with strong oxidizing agents, strong acids. | | InChIKey | BHHGXPLMPWCGHP-UHFFFAOYSA-N | | LogP | 1.46 | | CAS DataBase Reference | 64-04-0(CAS DataBase Reference) | | NIST Chemistry Reference | Benzeneethanamine(64-04-0) | | EPA Substance Registry System | Phenethylamine (64-04-0) |
| Hazard Codes | C | | Risk Statements | 22-34 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 2922 8/PG 2 | | WGK Germany | 1 | | RTECS | SG8750000 | | F | 9-23 | | Autoignition Temperature | 425 °C | | TSCA | Yes | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29214980 | | Hazardous Substances Data | 64-04-0(Hazardous Substances Data) | | Toxicity | LD50 orally in Rabbit: 300 mg/kg |
| | 2-PhenylethylaMine Usage And Synthesis |
| Chemical Properties | Phenethylamine has a fish odor. | | Chemical Properties | colourless or slightly yellow liquid with | | Occurrence | Reported found in the oil of bitter almonds. Also found in grapes, cabbage, kale, carrots, blue and provolone
cheese, fatty fish, beer, sherry, grape wines, cocoa, cauliflower, beetroot, radish, rhubarb, sake and dried bonito. | | Uses | Phenethylamine is used in manufacturing anti-depression agents and anti diabetic drugs. It is also used as the goodds for drug jiangtangling intermediate, also used for other organic synthesis. | | Definition | ChEBI: A phenylethylamine having the phenyl substituent at the 2-position. | | Preparation | By reduction of benzyl cyanide with sodium metal in alcohol or with Raney-Ni. | | Synthesis Reference(s) | Chemical and Pharmaceutical Bulletin, 34, p. 3905, 1986 DOI: 10.1248/cpb.34.3905
Journal of the American Chemical Society, 94, p. 6561, 1972 DOI: 10.1021/ja00773a060
Tetrahedron Letters, 21, p. 1719, 1980 DOI: 10.1016/S0040-4039(00)77819-1 | | General Description | Phenethylamine, a new stimulant designer drug, was analyzed by the liquid chromatography high-resolution mass spectrometry quadrupole-time-of-flight (LC-HRMS-QTOF) method. | | Safety Profile | Poison by intraperitoneal, subcutaneous, intracervical, and intravenous routes. Moderately toxic by ingestion. A strong base. A skin irritant and possible sensitizer. When heated to decomposition it emits toxic fumes of NOx. See also AMINES | | Purification Methods | Distil the amine from CaH2, under reduced pressure, just before use. [Beilstein 12 H 1096, 12 IV 2453.] |
| | 2-PhenylethylaMine Preparation Products And Raw materials |
| Raw materials | Ammonia-->Nickel | | Preparation Products | 2-(PIPERAZIN-1-YL)-ACETIC ACID N-(2-PHENYLETHYL)-AMIDE-->1,2,3,4-TETRAHYDROISOQUINOLINE-->FLUCYTHRINATE-->N-BENZYL-2-PHENYLETHYLAMINE-->7-Aminoisoquinoline-->7-NITRO-3,4-DIHYDROISOQUINOLINE-->3,4-DIHYDROISOQUINOLINE-->2-(2-NITROPHENYL)ETHANAMINE-->Glipizide-->4-NITRO-PHENETHYLAMINE-->Triethyl 1,3,5-benzenetricarboxylate-->2-CYCLOHEXYL-ETHYLAMINE HYDROCHLORIDE-->2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINE-->7-AMINO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE-->2-Aminoecetophenone |
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