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| | 2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E Basic information |
| Product Name: | 2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E | | Synonyms: | 2-[2,6-Difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]acetamide;2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide (PEPA);PEPA,inhibit,Inhibitor,iGluR,Ionotropic glutamate receptors;Acetamide, 2-[2,6-difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]- | | CAS: | 141286-78-4 | | MF: | C16H16F2N2O4S2 | | MW: | 402.44 | | EINECS: | | | Product Categories: | | | Mol File: | 141286-78-4.mol |  |
| | 2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E Chemical Properties |
| Boiling point | 617.6±65.0 °C(Predicted) | | density | 1.47±0.1 g/cm3(Predicted) | | storage temp. | protect from light | | solubility | DMSO: >20mg/mL | | form | solid | | pka | 10.44±0.40(Predicted) | | color | white | | InChIKey | GTACSIONMHMRPD-UHFFFAOYSA-N |
| | 2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E Usage And Synthesis |
| Uses | PEPA is an allosteric potentiator of AMPA desensitization. | | Biological Activity | Novel allosteric potentiator of AMPA receptor desensitization. Slows the rate of onset of desensitization and potentiates steady-state equilibrium currents induced by glutamate with subunit (GluR3/4 > GluR1) and splice variant (flop > flip) selectivity. Ameliorates post-ischemic memory impairment in rats following i.v. administration. | | Biochem/physiol Actions | 2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide is a structurally novel, selective, high affinity AMPA ionotropic glutamate receptor agonist that reduces ischemia-induced performance deficits in rats. |
| | 2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E Preparation Products And Raw materials |
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