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| (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol Basic information |
| (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol Chemical Properties |
Melting point | 77-80 °C | alpha | 59 º (589nm, c=3, MeOH 25 ºC) | Boiling point | 396.54°C (rough estimate) | density | 1.0078 (rough estimate) | refractive index | 58 ° (C=2, MeOH) | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | solubility | almost transparency in Chloroform | form | solid | pka | 13.15±0.29(Predicted) | color | white to off-white | optical activity | [α]20/D +69°, c = 3 in chloroform | BRN | 4353363 | InChIKey | OGCGXUGBDJGFFY-MRXNPFEDSA-N | CAS DataBase Reference | 22348-32-9(CAS DataBase Reference) | NIST Chemistry Reference | (R)-alpha-(2-pyrrolidinyl)benzhydryl alcohol(22348-32-9) |
| (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol Usage And Synthesis |
Chemical Properties | white to faintly yellow crystalline powder | Uses | Used to prepare the corresponding oxazaborolidines for the borane-mediated asymmetric reduction of ketones. | Uses | suzuki reaction | Definition | ChEBI: (r)-alpha,alpha-diphenyl-2-pyrrolidinemethanol is a diarylmethane. | Synthesis | Draw 14 kg of tetrahydrofuran into the reaction kettle. 61.5 kg of a 34% strength solution of phenylmagnesium chloride in tetrahydrofuran was added to the reaction vessel to initiate agitation and cooling cycles. The control temperature is 10 to 60 °C. The dropping time was controlled for 5 to 6 hours, and stirring was continued for 1 hour. Pump 24 kg of concentrated hydrochloric acid (mass concentration 36%) into the matching drip tank of the reaction kettle. constantly dropping, the dropping time is controlled for 1 hour, and the dropping process control temperature does not exceed 45 ° C. After the addition was completed, stirring was continued for 8 hours.Cool down to -5 ° C ~ 5 ° C to obtain (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol, a total of 17.2 kg, yield 85%. |
| (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol Preparation Products And Raw materials |
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