|
|
| | 2-(Di-tert-butylphosphino)biphenyl Basic information | | Reactions |
| | 2-(Di-tert-butylphosphino)biphenyl Chemical Properties |
| Melting point | 86-88 °C (lit.) | | Boiling point | 405.5±24.0 °C(Predicted) | | density | 1 g/cm3 | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly, Heated, Sonicated) | | form | Crystals or Crystalline Powder | | color | White | | Water Solubility | Insoluble | | BRN | 8322131 | | Stability: | Air Sensitive | | InChIKey | CNXMDTWQWLGCPE-UHFFFAOYSA-N | | CAS DataBase Reference | 224311-51-7(CAS DataBase Reference) |
| | 2-(Di-tert-butylphosphino)biphenyl Usage And Synthesis |
| Reactions |
- Ligand used in the palladium-catalyzed synthesis of aromatic amines from aryl chlorides, bromides and triflates.
- Ligand employed in a very active and general catalyst for Suzuki coupling reactions using aryl chlorides, bromides and triflates.
- Ligand used in palladium-catalyzed synthesis of oxindoles from α-chloroacetanilides.
- Effective ligand used in palladium-catalyzed arylation of thiazoles.
- Used in the formation of 2-benzylindolines via sequential palladium-catalyzed N-arylation/cyclization/C-arylation.
- Selective in the palladium-catalyzed arylation of silyl enol ethers formed from copper-catalyzed reduction of enones.
| | Chemical Properties | white to light yellow crystal powde | | Uses | suzuki reaction | | Uses | 2-(Di-tert-butylphosphino)biphenyl (also known as JohnPhos) is a Buchwald ligand that is highly efficient in palladium-catalyzed reactions. | | General Description | JohnPhos is a Buchwald′s sterically bulky biaryl phosphine ligand. It is a reactive dialkylbiaryl phosphine ligand which catalyzes the carbon-nitrogen bond-forming reactions. Coordination chemistry of gold catalysts bearing JohnPhos as ligand has been investigated by NMR spectroscopy. |
| | 2-(Di-tert-butylphosphino)biphenyl Preparation Products And Raw materials |
|