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2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Suppliers list
Company Name: Qingdao Truelight functional Material Technology Co., Ltd.
Tel: +86-13573844393
Email: songjames@truelightchem.com
Products Intro: Product Name:UV ABSORBER TRUELICHT BP-4
CAS:4065-45-6
Purity:98.0% Package:1KG;0.00;USD
Company Name: career henan chemical co
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Products Intro: Product Name:2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
CAS: 4065-45-6
Purity:99% Package:1KG;25USD
Company Name: QINGDAO JADE NEW MATERIAL TECNOLOGY CO.,LTD
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Products Intro: Product Name:uv absorber BP-4
CAS:4065-45-6
Purity:98% Package:20KG;USD Remarks:uv absorber BP-4
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
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Products Intro: Product Name:benzophenone-4
CAS:4065-45-6
Purity:USP BP Package:25ASSAYS;2USD
Company Name: Wuhan Fortuna Chemical Co.,Ltd
Tel: +8618007136271
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Products Intro: Product Name:2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
CAS:4065-45-6
Purity:99% Package:1kg;|25kg

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid manufacturers

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Basic information
Product Name:2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
Synonyms:Uvistat 1121;UV ABSORBER HMBS;TIMTEC-BB SBB002961;spectra-sorb uv 284;2-HYDROXY-4-METHOXYBENZOPHENONE-5-SULFONIC ACID;2-HYDROXY-4-METHOXYBENZOPHENONE-5-SULFONIC ACID HYDRATE;2-HYDROXY-4-METHOXY-5-SULFOBENZOPHENONE;2-HYDROXY-4-METHOXY-5-SULFONYLBENZOPHENONE
CAS:4065-45-6
MF:C14H12O6S
MW:308.31
EINECS:223-772-2
Product Categories:Organic acids;Industrial/Fine Chemicals;Aromatic Benzophenones & Derivatives (substituted);SUNGARD;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfonic/Sulfinic Acids;Sulfur Compounds;4065-45-6
Mol File:4065-45-6.mol
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Structure
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Chemical Properties
Melting point 170 °C
Boiling point 0°C
density 1.4574 (rough estimate)
vapor pressure 0Pa at 25℃
refractive index 1.5300 (estimate)
Fp 0°C
storage temp. Inert atmosphere,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka-0.70±0.50(Predicted)
form Solid
color White to Off-White
Water Solubility 300.92g/L at 25℃
Merck 14,8983
BRN 2889165
InChIKeyCXVGEDCSTKKODG-UHFFFAOYSA-N
LogP0.515 at 25℃
CAS DataBase Reference4065-45-6(CAS DataBase Reference)
EPA Substance Registry SystemSulisobenzone (4065-45-6)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39-36/37/39-27
WGK Germany 1
RTECS DB5044300
TSCA Yes
HS Code 29147000
Hazardous Substances Data4065-45-6(Hazardous Substances Data)
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Usage And Synthesis
DescriptionUV light absorber 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid (INCI title Benzophenone-4; Hereinafter to be referred to as BP-4) can absorb UV-A and UV-B simultaneously; Be a kind of wide spectrum, water-soluble UV light absorber; To advantages such as light, Heat stability is goods, be used for water-soluble makeup and make sun-screening agent. Being the cosmetics additive that Europe and Japanese rules allow use, it is also the first kind of sun-screening agent of drugs approved by the FDA and is simultaneously the UV light absorber that China's cosmetics health standard (2002 editions) permission. Its acute toxicity: the oral medium lethal dose LD50=3530mg/kg of mouse belongs to the low toxicity chemical.
Chemical Propertieswhite to yellowish powder
OriginatorUval,Dome,US,1965
UsesUltraviolet absorber for leather and textile fibers; in cosmetics and shampoos.
Uses 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid is a commonly used, FDA approved sunscreen chemical with uVA-absorbing properties and an approved usage level of 5 to 10 percent. It protects a formulation from the effects of uV-light exposure. Sulisobenzone is the drug name for benzophenone-4, a sunscreen chemical.
DefinitionChEBI: Sulisobenzone is a member of benzophenones.
Manufacturing Process663 g of dichloroethane and 74.6 g 2-hydroxy-4-methoxybenzophenone were charged into a 3-neck flask equipped with stirrer, thermometer, reflux condenser and dropping funnel and a heating mantle. The solution was heated to the reflux temperature (85°C to 86°C) and was dehydrated by distilling off 66.5 g 1,2-dichloroethane. While maintaining at reflux, 30 g chlorosulfonic acid was added slowly over a period of about two hours. The rate of addition was regulated by the speed of evolution of the HCl. After all the chlorosulfonic acid was added, the charge was still maintained at reflux for an additional 15 minutes to remove traces of HCl. It was then cooled to 5°C and filtered. The filter cake was washed with 500 g cold 1,2-dichloroethane and dried. 98 g of product were obtained.
Brand nameSungard (Bayer).
Therapeutic FunctionSunscreen agent
General DescriptionSulisobenzone is a broad spectrum organic UV filter in sunscreen formulations, known to absorb deleterious UV light.
Flammability and ExplosibilityNon flammable
Contact allergensBZP-4 is widely used in cosmetics, particularly shampoos and hair products. Cross-reactivity is rarely expected in patients photoallergic to ketoprofen.
SynthesisAdding 2-hydroxy-4-methoxybenzophenone and a solvent into an enamel reaction kettle, dripping chlorosulfonic acid under the protection of nitrogen with stirring, controlling the temperature of materials in the kettle to be 20 to 25 DEG C through jacket water bath cooling by controlling the dripping speed of the chlorosulfonic acid, and reacting for 20 to 25 hours; performing centrifugal filtering separation on a product after the reaction is finished, washing the product by using the corresponding solvent, and drying the product under the protection of the nitrogen; and recycling a hydrogen chloride (HCl) byproduct in an HCl recycling packed tower in a water circulation mode to form a 20 to 30 % hydrochloric acid aqueous solution, and recycling the 2-hydroxy-4-methoxybenzophenone and the 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid from raffinate at the bottom of the kettle.
Regulations2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid is a cosmetic material; the allowance state of countries in the world (maximum usage quantity wt%) is as follows: Europe: 5.0%; Australia: 10%; Japan: 10.0%; The U.S.: 10.0%; China: 5%.
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Preparation Products And Raw materials
Raw materialsResorcinol-->1,3-Dimethoxybenzene-->Oxybenzone-->Chlorosulfonic acid
Tag:2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid(4065-45-6) Related Product Information
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