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| | NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE Basic information |
| Product Name: | NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE | | Synonyms: | NG,NG-Dimethylarginine Dihydrochloride Solution, 100ppm;asym-Dimethylarginine, ADMA;NG,NG-dimethyl-L-Arginine (hydrochloride);(S)-2-aMino-5-(3,3-diMethylguanidino)pentanoic acid dihydrochloride;NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE;NG,NG-DIMETHYLARGININE, DIHYDROCHLORIDE;N5-[(DIMETHYLAMINO)IMINOMETHYL]-L-ORNITHINE, DIHYDROCHLORIDE;ADMA | | CAS: | 220805-22-1 | | MF: | C8H20Cl2N4O2 | | MW: | 275.18 | | EINECS: | | | Product Categories: | Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 220805-22-1.mol |  |
| | NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE Chemical Properties |
| Melting point | 202-204OC | | storage temp. | room temp | | solubility | DMSO (Slightly, Heated, Sonicated), Methanol (Slightly), Water (Slightly) | | form | White to off-white crystalline solid. | | color | White to Off-White | | Water Solubility | Soluble in water (100 mM) | | Stability: | Store at 0-5°C; Moisture Sensitive; Hygroscopic | | CAS DataBase Reference | 220805-22-1 |
| | NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE Usage And Synthesis |
| Chemical Properties | White Crystalline Solid | | Uses | NG,NG- Dimethylarginine dihydrochloride has been used:
- to study its effects on cardiovascular activities in rostral ventrolateral medulla (RVLM) in rats
- as a standard for measuring L-arginine and dimethylarginines
- to study its effects on hepatic deterioration
| | Uses | A potent inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells | | General Description | NG,NG-Dimethylarginine dihydrochloride is a methylated arginine derivative, which is produced by the liver. It is linked to liver cirrhosis, alcoholic hepatitis and acute liver failure (ALF). | | Biological Activity | ng,ng-dimethyl-l-arginine is an endogenous nitric oxide synthase inhibitor.nitric oxide (no) that is synthesised from l-arginine contributes to the regulation of blood pressure and to host defence. | | Biochem/physiol Actions | Reversible inhibitor of nitric oxide synthetase in vivo and in vitro. | | in vitro | ng,ng-dimethyl-l-arginine (adma) was found to be able to inhibit macrophage and vascular no synthase. when added to a cytosolic preparation of macrophage no synthase, adma could cause dose-dependent inhibition of no formation. in the presence of added arginine, adma could inhibited no synthesis and the inhibitory effects of adma were prevented by addition of l-arginine so that the rate of no synthesis did not significantly differ from control values [1]. | | in vivo | animal study showed that the injection of 1-30 mg/kg adma into 3 anaesthetised guineapigs could cause dose-dependent increases in mean arterial blood pressure. moreover, during continuous infusion of adma, which caused plasma adma concentrations to rise approximately 9-fold, the systolic blood pressure was raised by nearly 15 % [1]. | | storage | Room temperature (desiccate) | | references | [1] vallance, p. ,leone, a.,calver, a., et al. accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. lancet 339, 572-575 (1992). |
| | NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE Preparation Products And Raw materials |
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