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ChemicalBook > Product Catalog >Biochemical Engineering >Amino Acids and Derivatives >Arginine derivatives >N'-Nitro-L-arginine-methyl ester hydrochloride

N'-Nitro-L-arginine-methyl ester hydrochloride

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Company Name: Capot Chemical Co.,Ltd.
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Products Intro: Product Name:H-Arg(NO2)-OMe?¤HC
CAS:51298-62-5
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Shanghai Daken Advanced Materials Co.,Ltd
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Products Intro: Product Name:H-Arg(NO2)-Ome.HCl
CAS:51298-62-5
Purity:99% Package:5G;100G;1KG;648KG
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Products Intro: Product Name:N'-Nitro- L- Arginine methyl ester hydrochloride
CAS:51298-62-5
Purity:99% Package:25KG;5KG;1KG
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Products Intro: Product Name:H-Arg(NO2)-Ome·HCl
CAS:51298-62-5
Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG
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Products Intro: Product Name:N'-Nitro-L-arginine-methyl ester hydrochloride
CAS:51298-62-5
Purity:99% Package:1KG;1USD

N'-Nitro-L-arginine-methyl ester hydrochloride manufacturers
N'-Nitro-L-arginine-methyl ester hydrochloride Basic information
Product Name:N'-Nitro-L-arginine-methyl ester hydrochloride
Synonyms:H-L-Arg(NO2)-OMe*HCl;H-Arg(NOZ)-OMe.HCl;methyl N5-[imino(nitroamino)methyl]-L-ornithine monohydrochloride;H-Ala(NO2)-OMeHCl;H-Ala(No2)-Omecl;ω-Nitro-L-arginine methyl·hydrochloric acid;NG-Nitro-L-arginine-methyl ester hydrochloride,98%;Nω-Nitro-L-arginine methyl ester hydrochloride ,98%
CAS:51298-62-5
MF:C7H16ClN5O4
MW:269.69
EINECS:257-116-1
Product Categories:Inhibitors;Arginine [Arg, R];Amino Acids and Derivatives;Amino hydrochloride;Nitric Oxide;Signalling;Amino Acids Derivatives;Amino Acids;Amino Acid Methyl Esters;Amino Acids (C-Protected);Biochemistry
Mol File:51298-62-5.mol
N'-Nitro-L-arginine-methyl ester hydrochloride Structure
N'-Nitro-L-arginine-methyl ester hydrochloride Chemical Properties
Melting point 157-161 °C (dec.)
alpha 14.5 º (c=3, CH3OH)
RTECS RM2982570
refractive index 15 ° (C=3, MeOH)
storage temp. -20°C
solubility H2O: 50 mg/mL
form powder
color white to off-white
Water Solubility almost transparency
BRN 3744166
InChIKeyQBNXAGZYLSRPJK-JEDNCBNOSA-N
CAS DataBase Reference51298-62-5(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 22-24/25-36-26
WGK Germany 3
HS Code 29299090
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
N'-Nitro-L-arginine-methyl ester hydrochloride Usage And Synthesis
DescriptionL-NAME requires hydrolysis of the methyl ester by cellular esterases to become a fully functional inhibitor (L-NNA). L-NNA exhibits some selectivity for inhibition of neuronal and endothelial isoforms. It exhibits Ki values of 15 nM, 39 nM, and 4.4 μM for nNOS (bovine), eNOS (human), and iNOS (mouse), respectively. The reported Ki value for the inhibition of iNOS ranges from 4-65 μM. L-NAME inhibits cGMP formation in endothelial cells with an IC50 of 3.1 μM (in the presence of 30 μM arginine) and reverses the vasodilation effects of acetylcholine in rat aorta rings with an EC50 of 0.54 μM.
Chemical PropertiesCrystalline
UsesNitroarginine Methyl Ester Hydrochloride is used in the synthesis of N/CD13 inhibitors playing an important role in tumor invasion, metastatsis and angiogenesis. Also used in the preparation of spirocyclic lactam as a type II’ β-turn inducer.
DefinitionChEBI: A hydrochloride obtained by combining Ngamma-nitro-L-arginine methyl ester with one equivalent of hydrochloric acid.
General DescriptionMore soluble analog of arginine and a competitive, slowly reversible inhibitor of endothelial nitric oxide synthase (IC50 = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC50 = 400 nM).
Biological ActivityNO synthase inhibitor.
Biochem/physiol ActionsPrimary TargeteNOS
storageRoom temperature
N'-Nitro-L-arginine-methyl ester hydrochloride Preparation Products And Raw materials
Tag:N'-Nitro-L-arginine-methyl ester hydrochloride(51298-62-5) Related Product Information
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