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Panipenem

Panipenem Suppliers list
Company Name: LGM Pharma  
Tel:1-(800)-881-8210
Email:inquiries@lgmpharma.com
Products Intro:Product Name:PanipeneM
CAS:87726-17-8
Purity:Typically NLT 98%
Company Name: Beijing Lunarsun Pharmaceutical Co.,LTD.  
Tel:86-10-64911848-8020.8010
Email:sales@lunarsun.com.cn
Products Intro:Product Name:Panipenem
CAS:87726-17-8
Purity:99% Package:On Request
Company Name: Hangzhou Yuhao Chemical Technology Co., Ltd  
Tel:0571-82693216
Email:info@yuhaochemical.com
Products Intro:Product Name:PanipeneM
CAS:87726-17-8
Company Name: BOC Sciences  
Tel:1-631-504-6093
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Products Intro:Product Name:PanipeneM
CAS:87726-17-8
Company Name: Wuhan Fortuna Chemical Co., Ltd  
Tel:+86-27-59207852 85767163
Email:info@fortunachem.com
Products Intro:Product Name:Panipenan
CAS:87726-17-8
Purity:99% Package:25kg/drum
Panipenem Basic information
Carbapenems Three kinds of carbapenems contrast Adverse reactions
Product Name:Panipenem
Synonyms:PANIPENEM;(5r,6s)-2-[1-acetamidoylpyrrolidin-3(s)-ylthio]-6-[1(r)-hydroxyethyl]-2-carbapenem-3-carboxylic acid;(5r-(3(s*),5-alpha,6-alpha(r*)))-inoethyl)-3-pyrrolidinyl)thio)-7-oxo;1-azabicyclo(3.2.0)hept-2-ene-2-carboxylicacid,6-(1-hydroxyethyl)-3-((1-(1-im;6-(1-hydroxyethyl)-2-(1-acetimidoylpyrrolidin-3-ylthio)-1-carbaren-2-em-3-ca;carbapenemrs-533;cs533;FAROPENEM, 90.0%
CAS:87726-17-8
MF:C15H21N3O4S
MW:339.41
EINECS:
Product Categories:Antibacterial
Mol File:87726-17-8.mol
Panipenem Structure
Panipenem Chemical Properties
CAS DataBase Reference87726-17-8(CAS DataBase Reference)
Safety Information
MSDS Information
Panipenem Usage And Synthesis
CarbapenemsPanipenem is a carbapenem antibiotic,it is successfully developed by Japan Sankyo ,it has a broad antimicrobial spectrum , and it has strong antibacterial activity. This product is more stable, and its antibacterial spectrum is similar to imipenem ,it has a strong antibacterial effect on Gram-positive bacteria and negative bacteria, aerobic and anaerobic bacteria ,its effect on Staphylococcus aureus and methicillin-resistant Staphylococcus aureus is superior to that of imipenem, its effect on Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae, indole-positive and negative Proteus, Citrobacter, Serratia bacteria is stronger than imipenem, the effect on Pseudomonas aeruginosa is slightly lower than imipenem. To further enhance security, the antibiotic and kidney-protecting agent organic ion transport inhibitors Betamipron as 1:1 ratio are usd for the synthesis of compound preparation, Betamipron does not inhibit the dehydrogenation peptidase,it also has no inhibitory and other pharmacological effects, it only suppresses organic ion transport,it reduces kidney toxicity, it is clinically used for the treatment of bacteremia, sepsis, cholecystitis, liver abscess, peritonitis, inflammation of the eye, otitis media, endocarditis, skin and soft tissue infections, lower respiratory tract infections, genitourinary infections, gynecological infections caused by staphylococcus, streptococcus, enterococcus and other sensitive strains.
Three kinds of carbapenems contrastMeropenem, imipenem and panipenem these three carbapenems all have good antibacterial activity on all kinds of G + and G-bacteria bacteria, aerobic and anaerobic bacteria ,they are clinically used for severe infections, mixed infections, nosocomial infections, and immunocompromised infection caused by production enzyme strains, and multi-drug resistant strains and G-mainly bacteria.
The differences between the three are as follows:
1, each has different focuses,their anaerobic antibacterial spectrums are similar ; for unfermentable negative bacteria of the aerobic , meropenem is the most active, followed by imipenem, panipenem. For G + bacteria, panipenem is the strongest.
2, imipenem has the highest incidence of adverse reactions on the central nervous system , meropenem and panipenem are lower.
3, imipenem is instable to human renal dehydropeptidase,it should to be added with the enzyme inhibitor cilastatin. And meropenem and panipenem are stable to human renal dehydropeptidase. Panipenem have some kidney toxicity, often plus betamethasone in order to reduce nephrotoxicity.
4, imipenem and panipenem are only available for intravenous, intramuscular meropenem can be used.
The above information is edited by the chemicalbook of Tian Ye.
Adverse reactions Patients allergic to β-lactam antibiotics are banned.
The elderly, pregnant women, young children and kidney dysfunction patients should use with caution.
Diarrhea, belching, vomiting, rash.
Reduce the number of red blood cells and white blood cells, increase eosinophils.
UsesPanipenem is a broad spectrum carbapenem antibacterial and antimicrobial agent working against Gram-negative and Gram-positive organisms.
Panipenem Preparation Products And Raw materials
Tag:Panipenem(87726-17-8) Related Product Information
2-(METHYLSULFONYL)ETHANOL panipenem-betamipron (AZETIDIN-3-YL)METHANOL Panipenem Tetrahydro pyrrole Polyvinylpyrrolidone 1-Methyl-2-pyrrolidinone 3,3-Dimethyl-D(-)-cysteine N-Vinyl-2-pyrrolidone