盐酸克林沙星
| 中文名称 | 盐酸克林沙星 |
|---|---|
| 中文同义词 | 7-(3-氨基-1-吡咯烷基)-8-氯-1-环丙基-6-氟-1,4-二氢-4-氧代-3-喹啉羧酸盐酸盐;盐酸克林沙星;包被盐酸可林沙星;克林沙星盐酸盐 |
| 英文名称 | Clinafloxacin hydrochloride |
| 英文同义词 | CLINAFLOXACIN HCL;CLINANFLOXACIN HYDROCHLORIDE;Clinafloxacinhydrochloride;7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride;7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-keto-quinoline-3-carboxylic acid hydrochloride;7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid hydrochloride;7-(3-azanylpyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-quinoline-3-carboxylic acid hydrochloride;3-Quinolinecarboxylic acid, 7-(3-aMino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, Monohydrochloride (9CI) |
| CAS号 | 105956-99-8 |
| 分子式 | C17H18Cl2FN3O3 |
| 分子量 | 402.25 |
| EINECS号 | |
| 相关类别 | 医用原料;医用原料;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;API |
| Mol文件 | 105956-99-8.mol |
| 结构式 |  |
盐酸克林沙星 性质
| 熔点 | 162-168°C |
|---|---|
| 储存条件 | Refrigerator |
| 溶解度 | DMSO（微溶）、甲醇（微溶）、水（微溶、加热） |
| 形态 | 固体 |
| 颜色 | 淡黄色至浅黄色 |
| 稳定性 | 吸湿性 |
MIC: 1 μg/ml (parC-gyrA mutants, S. pneumonia )
Clinafloxacin exhibits activity against S. pneumonia with an MIC of 1μg/ml for the parC-gyrA mutants.Clinafloxacin hydrochloride has antibacterial activities against target-altered mutant strains of S. aureus . It against Wild type S. aureus , gyr A mutant S. aureus and gyr A mutant S. aureus with MIC values of 0.016 µg/ml, 0.063 µg/ml and 0.915 µg/ml, respectively.
Clinafloxacin is very effective for the therapy of penicillin-resistant, ciprofloxacin-susceptible pneumococcal meningitis in the rabbit model. With the CS strain (2349)(Clinafloxacin MIC=0.12 μg/ml), at a dose of 10 mg/kg and 20 mg/kg per day Clinafloxacin achieves an initial reduction at 6 hr. Both are bactericidal at this point but presents regrowth at 24 hr, and the final reduction at 24 hr in mean log cfu/ml is 22.30 and 23.83, respectively. However, With the CR strain (4371)(Clinafloxacin MIC=0.5 μg/ml), Clinafloxacin even at 20 mg/kg per day does not decrease bacterial titers at any time point in this rabbit model of meningitis.