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DIMETHYLMERCURY

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  • Toxcity of Dimethylmercury
  • DMM has limited use because of its toxicity but can be used to calibrate research equipment, as in its application as a standa....
  • Oct 13,2021
DIMETHYLMERCURY Basic information
General Description Reaction Toxicity
Product Name:DIMETHYLMERCURY
Synonyms:(CH3)2Hg;dimethyl-mercur;Methyl mercury ion;MERCURY DIMETHYL;DIMETHYLMERCURY;Dimethylmercury(II);Dimethylmercury,98%;methylmercury II
CAS:593-74-8
MF:C2H6Hg
MW:230.66
EINECS:209-805-3
Product Categories:metal alkyl;Chemical Synthesis;Organomercury;Organometallic Reagents
Mol File:593-74-8.mol
DIMETHYLMERCURY Structure
DIMETHYLMERCURY Chemical Properties
Melting point −43 °C(lit.)
Boiling point 93-94 °C(lit.)
density 2.961 g/mL at 25 °C(lit.)
refractive index n20/D 1.543(lit.)
Fp 42 °F
storage temp. Flammables area
solubility insoluble in H2O; very soluble in ethanol, ethyl ether
form liquid
Water Solubility insoluble H2O; soluble ether, alcohol [MER06]
Merck 13,3276
BRN 3600205
Exposure limitsTLV-TWA: 0.01 mg (Hg)/m3 (ACGIH)
PEL-TWA: 0.01 mg (Hg)/m3 (OSHA)
STEL: 0.03 mg (Hg)/m3 (ACGIH)
The tolerable weekly intake (TWI) levels set by World Health Organization for methyl mercury is 1.6 μg/kg body weight. The reference dose (RfD) set by the U.S. EPA is 0.1 μg/kg body weight/day (Booth and Zeller (2005).
Stability:Stable. Highly flammable. Incompatible with strong oxidizing agents.
EPA Substance Registry SystemDimethylmercury (593-74-8)
Safety Information
Hazard Codes T+,N
Risk Statements 26/27/28-33-50/53
Safety Statements 13-28-36-45-60-61
RIDADR UN 3383 6.1/PG 1
WGK Germany 3
RTECS OW3010000
HazardClass 3.1
PackingGroup II
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
DIMETHYLMERCURY Usage And Synthesis
General DescriptionMercury dimethyl is a toxic environmental pollutant. It is found in polluted bottom sediments and in the bodies of fishes and birds. In the bodies of fishes and birds it occurs along with monomethyl mercury. The latter, as CH3Hg+ ion, is formed by microorganism-induced biological methylation of elemental mercury or agricultural fungicide mercury compounds that are discharged into the environment.
Mercury dimethyl is used in inorganic synthesis; and as a reference standard for Hg-NMR.
ReactionMercury dimethyl, unlike zinc dimethyl, is fairly stable at ordinary temperatures, and is not attacked by air or water.
Mercury dimethyl undergoes single replacement reactions with several metals such as alkali and alkaline earth metals, zinc, aluminum, tin, lead and bismuth forming their corresponding dialkyls.
Such reaction is a synthetic route to prepare many organometallic compounds. Thus, reaction with metallic zinc yields zinc dimethyl:
(CH3)2Hg + Zn → (CH3)2Zn + Hg
ToxicityMercury dimethyl is a highly toxic substance by all routes of exposure. Several cases of human poisoning are well documented. (Patnaik, P. 1999. A Comprehensive Guide to the Hazardous Properties of Chemical Substances, 2nd ed. p. 574, New York: John Wiley & Sons.) The compound can accumulate in the brain and blood of humans. Intake of small quantities can cause death.
DescriptionThe first indication of the extreme toxicity of dimethylmercury (DMM) was documented in 1863 when two laboratory assistants died of DMM poisoning while synthesizing DMM in the laboratory of Frankland and Duppa. There are numerous reports of people dying from alkyl mercury compounds including a chemist who was preparing several thousand grams ofDMMin his laboratory in 1974. The extreme toxicity was revisited in 1997, when Karen Wetterhahn, an internationally renowned researcher of the carcinogenic effects of heavy metals on DNA repair proteins, died within a few months after a single exposure of less than a milliliter of DMM on her latex-covered hand. DMM is extremely toxic and lethal at a dose of approximately 400 mg of mercury (equivalent to a few drops) or about 5mgkg-1 of body weight or as little as 0.1 ml
Chemical PropertiesDimethyl mercury is a volatile colorless liquid with faint sweet odor.
Chemical Propertiescolourless liquid
UsesDMM has limited use because of its toxicity but can be used to calibrate research equipment, as in its application as a standard reference material for 199Hg NMR measurements.
UsesDimethylmercury is used as a reagent ininorganic synthesis, and as a reference standardfor mercury nuclear magnetic resonance(Hg NMR). It is an environmental pollutantfound in bottom sediments and also inthe bodies of birds and marine mammalssuch as whales and fishes. It occurs in fishesand birds along with monomethylmercury. Inhumans, its presence is attributed to the consumptionof pilot whale meat, cod fish, andother sea food.
UsesAs inorganic reagent.
DefinitionChEBI: Dimethylmercury is a methylmercury compound.
Health HazardAll alkylmercury compounds are highly toxicby all routes of exposure. There are manyserious cases of human poisoning frommethylmercury (Lu 2003). Outbreaks ofmass poisoning from consumption of contaminatedfish occurred in Japan during the1950s, causing a severe neurological disease,so-called “Minamata disease,” whichresulted in hundreds of deaths. A similaroutbreak of food poisoning from contaminatedwheat caused several hundred deathsin Iraq in 1972. A tragic death from a singleacute transdermal exposure to dimethylmercury(estimated between 0.1 to 0.5 mL) thatpenetrated into the skin through disposablelatex gloves has occurred (Blayney et al.1997; The New York Times, June 11, 1997).The symptoms reported were episodes ofnausea and vomiting occurring three monthsafter the exposure followed by onset ofataxia, slurred speech (dysarthia), and loss ofvision and hearing 2 months after that. Thedeath occurred in about six months after theaccident.
Methylmercury can concentrate in certainfetal organs, such as the brain. Thetarget organs are the brain and the centralnervous system. It can cause death, miscarriage,and deformed fetuses. Unlike inorganicmercury compounds, it can penetrate throughthe membrane barrier of the erythrocyte,accumulating at about 10 times greater concentrationthan that in the plasma (WHO1976). Its rate of excretion on the bloodlevel is very slow. It gradually accumulatesin the blood. Such accumulation was found toreach 60% equilibrium at about 90 days, culminatedafter 270 days (Munro and Willes,1978). Skin absorption exhibits the symptomsof mercury poisoning. The toxic thresholdconcentration of mercury in the wholeblood is usually in the range 40 to 50 μg/L,while the normal range should be below10 μg/L.
Fire HazardIt is a flammable liquid; flash point 38°C (101°F). The flammability of this compound, its ease of oxidation and the energy of decomposition is relatively lower than the alkyls of lighter metals. It is mildly endothermic. The heat of formation, △H°f is +75.3 kJ/mol (Bretherick 1995). Unlike most other metal alkyls formed by elements of lower atomic numbers, dimethylmercury does not pose any serious fire or explosion hazard. Although it does not ignite in air, the compound is easily inflammable. It dissolves in lower alcohols without any violent decomposition. Heating with oxidizing substances can cause explosion. Violent explosion is reported with diboron tetrachloride at -63°C (-81°F) under vacuum (Wartik et al. 1971).
Safety ProfileSuspected carcinogen. Highly toxic. Mutation data reported. Easily flammable. When heated to decomposition it emits toxic fumes of Hg.
Potential ExposureDimethyl mercury has been used as seed disinfectants and for fungicides. It has also been used in organic synthesis.
Environmental FateDMM is a colorless liquid that is volatile at room temperature (vapor pressure 62.3 mmHg) and is slightly soluble in water (water solubility 8860 mg l-1). There are no reports on the partition behavior of DMM but it is known to readily evaporate and is thus rarely found in sediment or soil. No reports were found on the environmental persistence of DMM. While DMM vaporizes, no studies were found on long range transport. The lipophilicity ofDMMresults in its accumulation inadipose tissue, plasma proteins, and brain. DMM has not been found in fish.
ShippingUN2025 Mercury compounds, solid, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Toxicity evaluationIn contrast to the white crystalline solids of the pure forms of methylmercury (MMM) and phenylmercury, DMM exists as a colorless liquid at room temperature with high volatility. These physical qualities enable high concentrations of the substance to be absorbed by exposure pathways of the skin and lungs that circumvent first-pass elimination. Effectively, this prolongs the systemic circulation of DMM, and extends its residence time in the body.
The additional alkyl group flanking the mercury imparts DMM with lipophilicity that exceeds its monoalkylated counterpart, and allows DMM to be sequestered in lipid-rich depots. The metabolic delay allows the neurotoxicity of DMM to remain latent for months.
The gradual conversion into MMM results in the release of DMM from depots such as lipid-rich tissues and plasma proteins, and permits its movement through barriers such as the blood–brain and placenta. A cysteine complex of the monomethylated metabolite penetrates the endothelial cells of the blood–brain barrier by mimicking methionine and using the large neutral amino acid transporter.
Thus, the toxicity of DMM is mediated by its dealkylation. Cleavage of the carbon–mercury bond generates MMM metabolites, which can form covalent bonds with cellular ligands with amphiphilic properties. The mercury center reacts with sulfur and sulfur-containing thiol groups of enzymes and thereby inhibits them, resulting in cellular dysfunction.
The metal center of DMM acts as a soft acid, and binds tightly to polarizable donor atoms in soft bases. An additional mechanism of adverse effect is the disruption of the prooxidant– antioxidant balance, causing oxidative damage to biomolecules resulting cellular damage. Within cells, mercury may interact with a variety of proteins, particularly microsomal and mitochondrial enzymes. Recent studies demonstrated that the combined administration of the antioxidants N-acetyl cysteine, zinc, and selenium mitigated DMM acute and chronic toxicity by reducing enzymatic and cellular dysfunction.
IncompatibilitiesIncompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. May be sensitive to light.
Tag:DIMETHYLMERCURY(593-74-8) Related Product Information
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