PSEUROTIN A
中文名称 | PSEUROTIN A |
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中文同义词 | |
英文名称 | pseurotin |
英文同义词 | pseurotin;(5S,8S,9R)-8-Benzoyl-2-[(1S,2S,3Z)-1,2-dihydroxy-3-hexenyl]-9-hydroxy-8-methoxy-3-methyl-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione;PB-1;NSC 348694;1-Oxa-7-azaspiro[4.4]non-2-ene-4,6-dione, 8-benzoyl-2-[(1S,2S,3Z)-1,2-dihydroxy-3-hexen-1-yl]-9-hydroxy-8-methoxy-3-methyl-, (5S,8S,9R)-;(5S,8S,9R)-8-benzoyl-2-[(Z,1S,2S)-1,2-dihydroxyhex-3-enyl]-9-hydroxy-8-methoxy-3-methyl-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione |
CAS号 | 58523-30-1 |
分子式 | C22H25NO8 |
分子量 | 431.44 |
EINECS号 | |
相关类别 | 微生物代谢物;生物碱 |
Mol文件 | 58523-30-1.mol |
结构式 |
PSEUROTIN A 性质
熔点 | 126.0-126.9℃ |
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沸点 | 751.5±60.0 °C(Predicted) |
密度 | 1.41±0.1 g/cm3(Predicted) |
储存条件 | -20°C |
溶解度 | 溶于DMSO(10mg/ml) |
酸度系数(pKa) | 14.76±0.20(Predicted) |
形态 | 白色至类白色粉末。 |
颜色 | 白色 |
稳定性 | 可在-20°C下的DMSO中的溶液储存长达3个月。 |
Pseurotin A inhibits the expression of PCSK9 in HepG2 cells, with an IC
50
value of 1.2 μM. Pseurotin A (25-100 μM; 72 hours) significantly suppressed the PCSK9 level in a dose dependent manner in BT-474 and T47D BC cell lines. Pseurotin A (25-100 μM; 72 hours) significantly increases LDLR level in a dose dependent manner.
Pseurotin A (40-200 μM; 24-72 hours) shows anti-proliferative activity in the hormone-dependent BC cells.
Cell Viability Assay
Cell Line: | BT-474 cells, T47D cells |
Concentration: | 40-200 μM |
Incubation Time: | 24-72 hours |
Result: | Showed weak but time and dose-dependent inhibition of the growth of BT-474 and T47D BC cells, with gradual decrease of the IC 50 values over time (260.83-93.64 μM and 267.84-113.08 μM, respectively). |
Pseurotin A (10 mg/kg; p.o.; 7X/week, 30 days) shows anti-tumor activity.
Animal Model: | HFD-fed orthotopic athymic mice (bearing BT-474 tumor cells xenograft mode) |
Dosage: | 10 mg/kg |
Administration: | P.o.; 7X/week, 30 days |
Result: | Significantly suppressed the growth of BT474 tumors. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-138648 | PB1 | 1 mg | 1727元 | |
2024/08/19 | HY-138648 | PSEUROTIN A PB1 | 58523-30-1 | 5mg | 3800元 |