- NU 2058
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- $1.00 / 1g
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2020-01-15
- CAS:161058-83-9
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 1000KGS
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| | NU 2058 Basic information |
| Product Name: | NU 2058 | | Synonyms: | 6-(Cyclohexylmethoxy)-9H-purin-2-amine;2-aMino-6-purine;2-aMino-6-[(cyclohexylMethyl)oxy]purine;2-Amino-6-(cyclohexylmethoxy)purine;CS-2601;NU 2058;NU-2058;NU2058;NU-2058;O6-(CYCLOHEXYLMETHYL)GUANINE;NU2058> | | CAS: | 161058-83-9 | | MF: | C12H17N5O | | MW: | 247.3 | | EINECS: | | | Product Categories: | Protein Kinase;Cell Cycle Regulation | | Mol File: | 161058-83-9.mol |  |
| | NU 2058 Chemical Properties |
| Melting point | 199°C(lit.) | | Boiling point | 424.8±55.0 °C(Predicted) | | density | 1.52±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,2-8°C | | solubility | DMSO: 22 mg/mL | | form | powder to crystal | | pka | 7.36±0.20(Predicted) | | color | white | | λmax | 281nm(MeOH)(lit.) | | InChIKey | MWGXGTJJAOZBNW-UHFFFAOYSA-N |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36/37 | | WGK Germany | 3 | | HS Code | 2933.99.9000 |
| | NU 2058 Usage And Synthesis |
| Description | NU 2058 is an inhibitor of cyclin-dependent kinase 1 (Cdk1) and Cdk2 (IC50s = 7.0 and 17 μM, respectively). Increased Cdk activity is often associated with human tumors, and inhibitors of Cdks, including NU 2058, can arrest cell cycling in cancer cells in vitro. | | Uses | NU 2058 is an intermediate of NU 6140 (N925295), a cyclin-dependant kinase 2 inhibitor which demonstrates 10-36 fold selectivity against Cdk2-cyclin A. This selectivity induces cell-cycle arrest at the G2-M phase and potentiates the apoptotic effect of pacitaxel. | | Biological Activity | Cyclin-dependent kinase (cdk) 1 and cdk2 inhibitor (K i values are 5 and 12 μ M respectively). Inhibits growth of human tumor cells in vitro (mean GI 50 = 13 μ M). Also inhibits DNA topoisomerase II ATPase activity (IC 50 = 300 μ M). | | storage | Store at +4°C |
| | NU 2058 Preparation Products And Raw materials |
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