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| | BUTYROLACTONE I Basic information |
| Product Name: | BUTYROLACTONE I | | Synonyms: | BUTYROLACTONE I;2,5-Dihydro-4-hydroxy-2-[4-hydroxy-3-(3-methyl-2-butenyl)benzyl]-3-(4-hydroxyphenyl)-5-oxofuran-2-carboxylic acid methyl ester;OloMoucin;2-Furancarboxylic acid, 2,5-dihydro-4-hydroxy-2-[[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]methyl]-3-(4-hydroxyphenyl)-5-oxo-, methyl ester, (2R)-;Butyrolactone I - CAS 87414-49-1 | | CAS: | 87414-49-1 | | MF: | C24H24O7 | | MW: | 424.44 | | EINECS: | | | Product Categories: | Antibiotic | | Mol File: | 87414-49-1.mol |  |
| | BUTYROLACTONE I Chemical Properties |
| Melting point | 74℃ | | Boiling point | 660.1±55.0 °C(Predicted) | | density | 1.353±0.06 g/cm3(Predicted) | | RTECS | LU0221600 | | storage temp. | Store at -20°C | | solubility | Soluble in ethanol at 25mg/ml or DMSO at 10mg/ml | | form | White solid. | | pka | 8.59±0.40(Predicted) | | color | White to off-white | | Sensitive | Light Sensitive |
| | BUTYROLACTONE I Usage And Synthesis |
| Uses | Butyrolactone I is one of a family of three butyrolactones isolated from Aspergillus fumigatus, first reported in 1983. Butyrolactone I exhibits antitumor activity, inhibiting the cell cycle at the G1/S and G2/M transitions. Butyrolactone I is a selective inhibitor of cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5, and is an important bioprobe for understanding the cellular roles of CDKs. | | Enzyme inhibitor | This natural product (FW = 424.45 g/mol), first identified in species of Aspergillus and named systematically as 2,5-dihydro-4-hydroxy 2-([4- hydroxy-3-(3-methyl-2-butenyl)phenyl]methyl)-3-(4-hydroxyphenyl)-5-oxo- 2-furancarboxylic acid methyl ester, competes with ATP in cyclindependent kinase reactions. The IC50 values for these kinases are typically 0.6-1.5 μM. Butyrolactone I also inhibits cell proliferation by the inhibiting pRb phosphorylation in IMR32 cells, causing both G1 and G2 arrest and stimulating apoptosis. Target(s): cyclin-dependent kinases 1 and 2; cdk5; protein kinase C; protein kinase A; MAP kinase; casein kinase II; [tau protein] kinase. | | storage | +4°C |
| | BUTYROLACTONE I Preparation Products And Raw materials |
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