盐酸去甲咪嗪
中文名称 | 盐酸去甲咪嗪 |
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中文同义词 | 盐酸去甲咪嗪;盐酸地昔帕明;盐酸去甲丙咪嗪;去甲丙咪嗪盐酸盐;[3-(10,11-二氢-5H-二苯并[B,F]氮杂卓-5-基)丙基]甲胺盐酸盐;盐酸去甲咪嗪杂质;3-(5,6-二氢苯并[B][1]苯并氮杂卓-11-基)-N-甲基-丙-1-胺;3-(5,6-二氢苯并[B][1]苯并氮杂卓-11-基)-N-甲基丙-1-胺 |
英文名称 | DESIPRAMINE HYDROCHLORIDE |
英文同义词 | Desipramine solution hydrochloride;RMI-9384A;10-11-Dihydro-N-methyl-5H-dibenz(Z)[b,f]azepine-5-propanaminehydrochloride;Desipramine Hydrochloride (125 mg);Desipramine Hydrochloride (125 mg)I0E2831.000mg/mg(dr);10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepine monohydrochloride;5-[3-(Methylamino)propyl]-5H-dibenz[b,f]azepine hydrochloride;10,11-dihydro-5-(3-(methylamino)propyl)-5h-dibenz(b,f)azepinehydrochloride |
CAS号 | 58-28-6 |
分子式 | C18H23ClN2 |
分子量 | 302.84 |
EINECS号 | 200-373-1 |
相关类别 | 合成;小分子抑制剂;标准品;医药原料;有机化工原料;临床检测标准物质;Intermediates & Fine Chemicals;Pharmaceuticals;Biogenic Amine Transport Inhibitors;Biogenic Amine Transport InhibitorsObesity Research;Neurotransmission;Neurotransmission (Obesity);Neurotransmitters;Adrenoceptor;NORPRAMIN |
Mol文件 | 58-28-6.mol |
结构式 |
盐酸去甲咪嗪 性质
熔点 | 214-2160C |
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闪点 | 11 °C |
储存条件 | 2-8°C |
溶解度 | H2O:50 mg/mL |
形态 | 粉末 |
颜色 | 白色至类白色 |
水溶解性 | Soluble to 100 mM in water |
Ki: 4 nM (NET), 61 nM (SERT), 78720 nM (DAT)
Treatment of rats with Desipramine hydrochloride for 14 days reduces norepinephrine transporter (NET) expression in a dose-dependent manner, as indicated by a reduction of the specific binding of 3 H-nisoxetine to the NET in preparations of cerebral cortex (F (3,16) =4.33, p<0.05) and hippocampus (F (3,16) =4.34, p<0.05). This NET down regulation is observed 2 days after discontinuation of chronic Desipramine hydrochloride treatment, a time when plasma and brain concentrations of Desipramine hydrochloride and desmethyldesipramine are undetectable (ie below the 25 ng detection limit of the assay).
安全信息
危险品标志 | Xn,T,F |
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危险类别码 | 22-36/37/38-42/43-48/23/24/25-23/24/25-11-39/23/24/25 |
安全说明 | 7-16-36/37-45-26-24-22 |
危险品运输编号 | UN 1230 3/PG 2 |
WGK Germany | 3 |
RTECS号 | HO0525000 |
海关编码 | 2933996100 |
毒性 | LD50 in mice, rats (mg/kg): 500, 385 orally; 94, 48 i.p.; 420, 183 s.c. (Eriksoo, Rohte) |
提供商 | 语言 |
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英文
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