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| Amcinafide Basic information |
Product Name: | Amcinafide | Synonyms: | Amcinafide;9-Fluoro-11β,21-dihydroxy-16α,17-[[(R)-1-phenylethylidene]bis(oxy)]pregna-1,4-diene-3,20-dione | CAS: | 7332-27-6 | MF: | C29H33FO6 | MW: | 496.572 | EINECS: | | Product Categories: | | Mol File: | 7332-27-6.mol | |
| Amcinafide Chemical Properties |
| Amcinafide Usage And Synthesis |
Originator | Amcinafide,Onbio Inc. | Uses | Anti-inflammatory. | Manufacturing Process | 1 ml 72% perchloric acid was added to a suspension of 4 g triamcinolone in
100 ml of fresh distilled acetophenone and the mixture was stirred at a room
temperature before all triamcinolone solved (for about 2 hours). The solution
was neutralized with help of 8 ml of 1.1 N sodium hydroxide and sufficient
quantity of sodium bicarbonate. Then chloroform and water were added.
Organic layer was separated and concentrated in vacuum. The residue was
recrystallized from acetone-hexane and thoroughly washed from
acetophenone with hexane. Triamcinolone acetophenide (amicinafide) was
prepared. It had MP: 281°-283°C (decomp.);αD
23 = +23°. (c = 0.98 in
CHCl3). | Therapeutic Function | Antiinflammatory, Antiallergic |
| Amcinafide Preparation Products And Raw materials |
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