| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:Guanabenz hydrochloride
CAS:23113-43-1
Purity:98% Package:1G;10G;100G Remarks:Guanabenz is an agonist of α2-adrenergic receptor with hypotensive effects.
|
| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
|
| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:Guanabenz hydrochloride
CAS:23113-43-1
Purity:≥98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
|
|
| | GUANABENZ HYDROCHLORIDE Basic information |
| Product Name: | GUANABENZ HYDROCHLORIDE | | Synonyms: | GUANABENZ HYDROCHLORIDE;Hydrazinecarboximidamide, 2-(2,6-dichlorobenzylidene)-, hydrochloride;1-{[(2,6-Dichlorophenyl)methylidene]amino}guanidine Hydrochloride;Guanabenzhydrochloride(Wytensin);NE56490;inhibit,Guanabenz hydrochloride,antiparasitic,Inhibitor,Beta Receptor,Guanabenz,Parasite,Adrenergic Receptor,antihypertensive,high blood pressure;2-(2,6-Dichlorobenzylidene)hydrazine-1-carboximidamide hydrochloride | | CAS: | 23113-43-1 | | MF: | C8H9Cl3N4 | | MW: | 267.54 | | EINECS: | | | Product Categories: | | | Mol File: | 23113-43-1.mol |  |
| | GUANABENZ HYDROCHLORIDE Chemical Properties |
| storage temp. | Store at -20°C | | solubility | ≥4.3 mg/mL in H2O; ≥4.37 mg/mL in EtOH; ≥9.25 mg/mL in DMSO | | form | A crystalline solid |
| | GUANABENZ HYDROCHLORIDE Usage And Synthesis |
| Description | Guanabenz is an α2-adrenergic receptor agonist (effective concentrations 10-100 nM) with hypotensive effects. It also competes for imidazoline I2-binding sites in brown adipose tissue (Ki = 97 nM). | | in vitro | maximum concentrations of guanabenz in plasma (1.2 to 5.2 ng/ml) reached 2 to 5 hours after administration of capsules containing 16 or 32 mg of 14c-labelled guanabenz. guanabenz was 90% bound to human plasma proteins [1]. guanabenz competed for imidazoline i2-binding sites in brown adipose tissue with ki of 97 nm [3]. | | references | [1] holmes b, brogden r n, heel r c, et al. guanabenz[j]. drugs, 1983, 26(3): 212-229.
[2] aantaa r, marjam ki a, scheinin m. molecular pharmacology of α2-adrenoceptor subtypes[j]. annals of medicine, 1995, 27(4): 439-449.
[3] rmer l, wurster s, savola j m, et al. identification and characterization of the imidazoline i2b-binding sites in the hamster brown adipose tissue as a study model for imidazoline receptors[j]. archives of physiology and biochemistry, 2003, 111(2): 159-166. |
| | GUANABENZ HYDROCHLORIDE Preparation Products And Raw materials |
|