| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Mefruside
CAS:7195-27-9
Package:10Mg,1Mg
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- mefruside
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- $1.00 / 1g
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2021-07-20
- CAS:7195-27-9
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 50tons
- mefruside USP/EP/BP
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- $1.10 / 1g
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2021-07-09
- CAS:7195-27-9
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100 Tons Min
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| | mefruside Basic information |
| Product Name: | mefruside | | Synonyms: | 1,3-Benzenedisulfonamide, 4-chloro-N1-methyl-N1-[(tetrahydro-2-methyl-2-furanyl)methyl]- (9CI);4-Chloro-N1-methyl-N1-(tetrahydro-2-methylfurfuryl)-m-benzenedisulfonamide;B 1500;BAY 1500;Baycaron;FBA 1500;FDA 1902;m-Benzenedisulfonamide, 4-chloro-N1-methyl-N1-(tetrahydro-2-methylfurfuryl)- (7CI, 8CI) | | CAS: | 7195-27-9 | | MF: | C13H19ClN2O5S2 | | MW: | 382.88 | | EINECS: | 2305624 | | Product Categories: | | | Mol File: | 7195-27-9.mol |  |
| | mefruside Chemical Properties |
| Melting point | 149.5°C | | Boiling point | 565.2±60.0 °C(Predicted) | | density | 1.3150 (rough estimate) | | refractive index | 1.6100 (estimate) | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 9.26±0.60(Predicted) | | color | White to Pale Beige | | Stability: | Hygroscopic |
| Toxicity | LD50 oral in rabbit: > 3gm/kg |
| | mefruside Usage And Synthesis |
| Originator | Baycaron,Bayer,W. Germany,1967 | | Uses | Mefruside is a diuretic used for the treatment of edema and hypertension. | | Definition | ChEBI: Mefruside is an organic molecular entity. | | Manufacturing Process | By hydrogenation of α-methyl-α-cyanotetrahydrofuran with Raney nickel as catalyst, α-methyl-α-tetrahydrofurfuryl amine is obtained (BP 48°C/12 mm Hg) which is alkylated by dimethyl sulfate to give α-methyl-αtetrahydrofurfurylmethylamine (BP 70°C/40 mm Hg). The amine is then reacted with 4-chloro-3-sulfamyl benzene sulfochloride in the presence of an acid acceptor. The mixture is stirred overnight, the solvent (acetone or pyridine) is driven off under vacuum and the residue is recrystallized from alcohol. | | Therapeutic Function | Diuretic |
| | mefruside Preparation Products And Raw materials |
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