- Chloromethyl pivalate
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- $5.00 / 25kg
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2024-04-26
- CAS:18997-19-8
- Min. Order: 1kg
- Purity: 99.92%
- Supply Ability: 50000tons
- Chloromethyl pivalate
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- $13.00 / 1000kg
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2024-01-18
- CAS:18997-19-8
- Min. Order: 1kg
- Purity: 99.0%
- Supply Ability: 500MT
- Chloromethyl pivalate
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- $30.00 / 1kg
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2023-11-18
- CAS:18997-19-8
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 20 tons
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| | Chloromethyl pivalate Basic information |
| | Chloromethyl pivalate Chemical Properties |
| | Chloromethyl pivalate Usage And Synthesis |
| Chemical Properties | Clear colorless to slightly yellow liquid | | Uses | Chloromethyl pivalate was used in the synthesis of pivaloyloxy methyl ester of ofloxacin as prodrug. It was used as the reagent during the synthesis of an isoindoline-annulated, tricyclic sultam library via microwave-assisted, continuous-flow organic synthesis. | | Application | Chloromethyl pivalate is a pharmaceutical intermediate compound used in the synthesis of active pharmaceutical ingredients. It is also involved in the acylation reaction with 9-(2-phosphonomethoxyethyl)adenine. It is used as a protecting agent for the N-protection of amines. It is also used in the preparation of thivaloyloxymethyl ester of ofloxacin as a prodrug. It is also used in the preparation of sulbactam pivoxil by reaction with the sodium salt of sulbactam. Besides, it is used as a reagent in the synthesis of isoindoline cyclic and continuous flow organic synthesis. | | General Description | Chloromethyl pivalate reacts with sodium salt of sulbactam to yield sulbactam pivoxil. It undergoes acylation reaction with 9-(2-phosphonylmethoxyethyl)adenine (PMEA) to yield bis(pivaloyloxymethyl) PMEA. | | Synthesis | Chloromethyl pivalate is prepared by the reaction of formaldehyd and pivaloyl chloride. The specific synthesis steps are as follows:
A mixture of pivaloyl chloride (8.56 g, 71 mmol), paraformaldehyde (2.13 g, 71 mmol) and zinc chloride (75 mg, 0.55 mmol) was stirred at 80 °C for 2 h. Purification by vacuum distillation afforded chloromethyl pivalate (41) as a colourless oil (6.29 g, 44.7 mmol, 59%). bp 80 °C/15 mmHg [lit.1 bp 80-81 °C/15 mmHg]; 1H NMR (400 MHz, CDCl3) δ 1.24 (9H, s, tBu), 5.72 (2H, s, CH2).
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| | Chloromethyl pivalate Preparation Products And Raw materials |
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