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BOC Sciences
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Product Name:3-Bromo-5-phenyl salicylic acid
CAS:4906-68-7
Purity:95% Package:1G;10G;100G Remarks:The aldo-keto reductase (AKR) enzymes constitute a family of related NADPH-dependent oxidoreductases. 3-Bromo-5-phenyl salicylic acid selectively inhibits AKR1C1 (Ki = 4 nM) over AKR1C2 (Ki = 87 nM)
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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Product Name:AKR1C1-IN-1
CAS:4906-68-7
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| | 3-bromo-5-phenyl Salicylic Acid Basic information |
| Product Name: | 3-bromo-5-phenyl Salicylic Acid | | Synonyms: | 3-bromo-5-phenyl Salicylic Acid;3-bromo-5-phenyl Salicylic Acid Exclusive;XVZSXNULHSIRCQ-UHFFFAOYSA-N;AKR1C1-IN-1;[1,1'-Biphenyl]-3-carboxylic acid, 5-bromo-4-hydroxy-;5-Bromo-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid;NSC-109116;3-bromo-5-phenylsalicyclic acid | | CAS: | 4906-68-7 | | MF: | C13H9BrO3 | | MW: | 293.11 | | EINECS: | | | Product Categories: | | | Mol File: | 4906-68-7.mol |  |
| | 3-bromo-5-phenyl Salicylic Acid Chemical Properties |
| Melting point | 212-214 °C | | Boiling point | 401.2±45.0 °C(Predicted) | | density | 1.611±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMF: 15 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 12.5 mg/ml; Ethanol: 0.1 mg/ml | | form | A crystalline solid | | pka | 2.45±0.14(Predicted) |
| | 3-bromo-5-phenyl Salicylic Acid Usage And Synthesis |
| Description | The aldo-keto reductase (AKR) enzymes constitute a family of related NADPH-dependent oxidoreductases. The 1C subfamily (AKR1C) includes four human hydroxysteroid dehydrogenases, with AKR1C1 being a 20α-HSD and the other three being 3α-HSDs. AKR1C1 metabolizes progesterone to an inactive progestin, 20α-hydroxy progesterone. In addition, AKR1C1 actions have been implicated in cancer and in the processing of neuroactive steroids involved in brain function. 3-bromo-5-phenyl Salicylic acid selectively inhibits AKR1C1 (Ki = 4 nM) over AKR1C2 (Ki = 87 nM), AKR1C3 (Ki = 4.2 μM), and AKR1C4 (Ki = 18.2 μM). Moreover, it potently inhibits the metabolism of progesterone by bovine aortic endothelial cells overexpressing AKR1C1 (IC50 = 460 nM). |
| | 3-bromo-5-phenyl Salicylic Acid Preparation Products And Raw materials |
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