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Topotecan hydrochloride

Topotecan hydrochloride Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
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Products Intro: CAS:119413-54-6
Purity:99% Package:500G;1KG;5KG;25KG
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Products Intro: Product Name:Topotecan hydrochloride
CAS:119413-54-6
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
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Products Intro: Product Name:Topotecan hydrochloride
CAS:119413-54-6
Purity:98% Package:71/KG
Company Name: SiChuang NanBu Honesty Technology Co., Ltd.  Gold
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Products Intro:Product Name:Topotecan hydrochloride
CAS:119413-54-6
Company Name: Tianyuan Natural Product Co.,Ltd.  Gold
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Products Intro:Product Name:Topotecan Hydrochloride
CAS:119413-54-6
Purity:99% HPLC Package:1KG;2KG;5KG
Topotecan hydrochloride Basic information
Anticancer drug Clinical studies Side effects Uses
Product Name:Topotecan hydrochloride
Synonyms:TOPOTECAN MONOHYDROCHLORIDE;TOPOTECAN HCL;SKF-104864A;9-[(DIMETHYLAMINO)METHYL]-10-HYDROXY-(20S)-CAMPTOTHECIN, HCL;(4S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4',6-7]INDOLIZINO[1,2-B]QUINOLINE-3,14(4H,12H)-DIONE;HYDROCHLORIDE;topetecan hydrochloride;5-PIPERAZIN-1-YL-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER
CAS:119413-54-6
MF:C23H24ClN3O5
MW:457.91
EINECS:
Product Categories:straight chain compounds;Active Pharmaceutical Ingredients;Anti-cancer & immunity;API;Antineoplastic;Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Isotope Labeled Compounds;Pharmaceuticals;Chiral Reagents;Inhibitors;Isotope Labelled Compounds
Mol File:119413-54-6.mol
Topotecan hydrochloride Structure
Topotecan hydrochloride Chemical Properties
Melting point 213-218°C
storage temp. Refrigerator
CAS DataBase Reference119413-54-6(CAS DataBase Reference)
Safety Information
Hazard Codes T
Risk Statements 25-36/37/38-46
Safety Statements 26-36/37/39-45
MSDS Information
Topotecan hydrochloride Usage And Synthesis
Anticancer drugTopotecan hydrochloride is a water-soluble derivative of camptothecin, which is the form of hydrochloride of topotecan. It is successfully developed by the SmithKline Beecham US company, and approved by the FDA in the United States in 1996. Its trade name is Hycamtin. It is applied in the treatment of ovarian cancer (OVC) as the second-line therapy.
In 1999 the US Food and Drug Administration (FDA) has approved topotecan hydrochloride as small cell lung cancer (SCLC) therapeutic drug. It has been available in the UK, Germany, France and other dozens of countries and regions. The Ⅲ clinical trials are ongoing for this medicine which is used to treat non-small cell lung cancer, cervical cancer, myelodysplastic syndrome.
Topotecan hydrochloride can enter the blood brain barrier. It has the same effect of oral and intravenous injection. The drug has low toxicity predictable bone marrow suppression, and other minor non-hematologic toxicity. Currently there are manufacturers, for clinical treatment of small cell lung cancer, ovarian cancer and other tumors.
Topotecan hydrochloride inhibits the activity of topoisomerase I, which is required for DNA replication. After intravenous injection, the product is hydrolyzed in the blood, and excreted by urinary. This product has a rapid serum clearance rate, which is 62L/h. It is widely distributed in vivo, and Its half-lifetime is about 2~3h. Preclinical trials have shown that the product has anti-tumor activity on all kinds of types of tumor. In I clinical trial, to patients with ovarian cancer that is cisplatin tolerance, this product also has significant anti-tumor effect.
Clinical studiesIn a open randomized trial, 226 cases who used cisplatin or carboplatin invalid or recurrent advanced ovarian cancer women changed to this product, and compared with paclitaxel. In 112 patients who used topotecan hydrochloride, 22 cases were effective, so the effective rate was 20%. In 114 patients treated with paclitaxel, 14 cases were effective, so the effective rate was 12%. Used this product for treatment which has made significant improvement in the average time of 23 weeks, while 14 weeks for paclitaxel. In a non-controlled trial to 111 women patients with refractory advanced ovarian cancer, 16 cases were preferabe after treatment, occupied with 14%, and the curative effect average time was 16-week, and the average survival time was 52-week. In an open trial, 67 cases were ineffective treated with cisplatin and paclitaxel for advanced ovarian cancer. However, 9 cases who changed to this product were effective, and the effective rate was 13%.
The above information is edited by the chemicalbook of Kui Ming.
Side effectsIt can appear toxicity of bone marrow suppression in limited doses, especially it can cause neutropenia. It often induced thrombocytopenia and anemia. Sometimes red blood cell and platelet transfusion is necessary. It can also be nausea, vomiting, hair loss, diarrhea, abdominal pain, gastritis and weakness, but all of them were mild.
UsesIt is used as antineoplastic agent.
Chemical PropertiesWhite Crystalline Solid
UsesNaturally occurring amino acid; precursor of tetrapyrroles in the biosynthesis of chlorophyll and heme. Antineoplastic (photosensitizer)
Usesantineoplastic; topoisomerase I inhibitor
UsesA DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic. Topotecan hydrochloride is a chemotherapy agent that is a topoisomerase 1 inhibitor.
Topotecan hydrochloride Preparation Products And Raw materials
Tag:Topotecan hydrochloride(119413-54-6) Related Product Information
(Diacetoxyiodo)benzene Irinotecan hydrochloride trihydrate Irinotecan hydrochloride 6,7-Dihydro-5H-pyrrolo[3,4-b]pyridine N-DESMETHYL TOPOTECAN CHEMBRDG-BB 9071233 2,4-HEXADIENYL PROPIONATE N-METHYL-1-QUINOLIN-5-YLMETHANAMINE C-QUINOLIN-5-YL-METHYLAMINE 4-ETHYL-4-HYDROXY-3,4,12,14-TETRAHYDRO-1H-PYRANO[3'4':6,7]INDOLIZINO[1,2-B]QUINOLINE-3,14-DIONE 2-Quinolinemethanamine (2-QUINOLYL)METHYLAMINE HYDROCHLORIDE 3-[(3-pyridylmethyl)amino]propanol 2-HYDROXY-PENT-4-ENOIC ACID 3-(2-PYRIDYLMETHYLAMINO)-1-PROPANOL DL-2-HYDROXY-3-BUTENOIC ACID METHYL ESTER 2-HYDROXY-2-METHYL-BUT-3-ENOIC ACID Topotecan hydrochloride