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| 2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID Basic information |
Product Name: | 2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID | Synonyms: | 2-(4-chlorophenyl)-4-thiazoleaceticaci;2-(4-chlorophenyl)-4-thiazoleaceticacid;2-(4-chlorophenyl)-thiazol-4-ylaceticacid;2-(p-chlorophenyl)-4-thiazoleaceticaci;2-(p-chlorophenyl)-4-thiazole-aceticacid;2-(p-chlorophenyl)thiazol-4-ylaceticacid;acidep-chlorophenyl-2thiazole-acetique-4;acidofenclozico | CAS: | 17969-20-9 | MF: | C11H8ClNO2S | MW: | 253.7 | EINECS: | | Product Categories: | | Mol File: | 17969-20-9.mol | ![2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID Structure](CAS/GIF/17969-20-9.gif) |
| 2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID Chemical Properties |
Melting point | 150-152°C | Boiling point | 145°C (rough estimate) | density | 1.2270 (rough estimate) | refractive index | 1.6300 (estimate) | storage temp. | 2-8°C | solubility | DMSO (Slightly), Methanol (Slightly) | form | Solid | pka | 3.83±0.10(Predicted) | color | Off-White to Pale Brown |
Hazard Codes | Xn | Risk Statements | 22 | HazardClass | IRRITANT | Toxicity | LD50 in rats, mice (mg/kg): 850, 1000 orally; 250, 300 i.v. (Hepworth) |
| 2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID Usage And Synthesis |
Originator | Fenclozic Acid,ZYF Pharm Chemical | Uses | Fenclozic Acid is a a potent antiinflammatory agent with analgesic and antipyretic properties and is a human hepatotoxic drug. | Manufacturing Process | 3.7 parts of 2-(4-chlorophenyl)-4-cyanomethylthiazole and 35 parts of 6 N
hydrochloric acid are heated under reflux for 2 hours. The solution is cooled
by the addition of ice and made alkaline to pH 8 by the addition of 30%
aqueous ammonia. The mixture is filtered to remove trace impurities, and an
excess of 40% sodium hydroxide solution is then added to the filtrate to cause
precipitation of a sodium salt, which is collected by filtration and crystallised
from water. There is thus obtained sodium 2-(4-chlorophenyl)thiazol-4-
ylacetate, M.P. 13°C (decomposition). This sodium salt is dissolved in hot water, and the solution is brought to pH 4
by the addition of acetic acid, which causes the precipitation of 2-(4-
chlorophenyl)thiazol-4-ylacetic acid. This is collected by filtration, washed with
water, and dried in vacuo over phosphorus pentoxide. It has an M.P. 155-
156°C (from ethyl acetate). | Therapeutic Function | Antiinflammatory, Analgesic, Antipyretic |
| 2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID Preparation Products And Raw materials |
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