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Olanzapine

Olanzapine Suppliers list
Company Name: Shanghai Boyle Chemical Co., Ltd.  
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Email:sales@boylechem.com
Products Intro:Product Name:Olanzapine
CAS:132539-06-1
Company Name: J & K SCIENTIFIC LTD.  
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Products Intro:Product Name:Olanzapine
CAS:132539-06-1
Purity:98.0%(GC&T) Package:1G,5G
Company Name: Taizhou Huading Chemical Co., Ltd  
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Products Intro:Product Name:Olanzapine
CAS:132539-06-1
Purity:99% Package:25kg,100kg,500kg
Company Name: INTATRADE GmbH  
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Products Intro:Product Name:Olanzapine
CAS:132539-06-1
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Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
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Products Intro:Product Name:Olanzapine
CAS:132539-06-1
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Olanzapine Basic information
Antipsychotics Chemical properties Uses Production method
Product Name:Olanzapine
Synonyms:3-b)(1,5)benzodiazepine,2-methyl-4-(4-methyl-1-piperazinyl)-10h-thieno(;Oltal;2-Methyl-4-(4-Methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiaze;Olanzapine (LY170053);10H-Thieno[2,3-b][1,5]benzodiazepine, 2-Methyl-4-(4-Methyl-1-piperazinyl)-;Olanzapine solution;Olanzapine for system suitability;Olanzapine, >=99%
CAS:132539-06-1
MF:C17H20N4S
MW:312.43
EINECS:200-835-2
Product Categories:API;ZYPREXA;Other APIs;Active Pharmaceutical Ingredients;APIs;Olanzapine;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;Heterocycles;Sulfur & Selenium Compounds
Mol File:132539-06-1.mol
Olanzapine Structure
Olanzapine Chemical Properties
Melting point 195°C
Fp 2℃
storage temp. -20°C Freezer
solubility DMSO: >15mg/mL
color yellow
CAS DataBase Reference132539-06-1(CAS DataBase Reference)
NIST Chemistry ReferenceOlanzapine(132539-06-1)
Safety Information
Hazard Codes Xi,Xn,F
Risk Statements 36/38-36-20/21/22-11
Safety Statements 26-36/37-16
RIDADR UN 2811 6.1 / PGIII
Olanzapine Usage And Synthesis
AntipsychoticsOlanzapine also known as olanzapine, olanzapine Oran, is a common antipsychotic drugs, clinically used to control schizophrenia, bipolar mania and agitation symptoms of dementia, it can significantly improve schizophrenia negative (for example: apathy, emotional and social withdrawal, poverty of speech), positive symptoms (such as: delusions, hallucinations, thought disorder, hostility and suspicion), and it may also relieve common secondary schizophrenia and related disorders affective symptoms.
Good oral absorption, it needs 5-8 hours to reach the peak plasma concentration, and it is not affected by eating, it is metabolized in the liver through a combination of oxidation ; the major circulating metabolite is the 10-N-glucuronide.
Animal experiments show that olanzapine displays affinity on multiple receptors 5-HT, dopamine D, α-adrenergic, histamine H et , the affinity with 5-HT2 receptor in vitro and in vivo is greater than its affinity for dopamine D2 receptors.
Animal behavior studies show that olanzapine has a 5-HT, dopamine, and cholinergic antagonism effect, and it is consistent with its receptor binding situation.
Electrophysiological studies show that olanzapine selectively reduces the limbic system (A10) dopaminergic neurons discharge, while the effect on the striatal (A9) motor path function is very small. In the reaction below to produce froze dosage levels, it can reduce the conditioned avoidance response. Different with other antipsychotics, olanzapine increases the anxiolytic response in test .
The above information is edited by the chemicalbook of Tian Ye.
Chemical propertiesCrystallization from acetonitrile, melting point of 195 ℃.
UsesUsed to control schizophrenia, bipolar mania and other diseases
Production method4-amino-2-methyl-10H-thieno [2,3-b] [1,5] benzo-diazepin-hydrochloride and N-methylpiperazine in toluene and dimethylsulfoxide , reflux under nitrogen for 20h, to obtain olanzapine.
Chemical PropertiesYellow Crystalline Powder
UsesA serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic activity. Antipsychotic.
Usesintermediate for Imidacloprid, Indobufen, Nitroguanidine, Nalorphine, Tazarotene, Trovafloxacin
Usesanti-ulcer, gastrointestinal-emptying agent enhances motility in the upper gastrointestinal tract
DefinitionChEBI: A benzodiazepine that is 10H-thieno[2,3-b][1,5]benzodiazepine substituted by a methyl group at position 2 and a 4-methylpiperazin-1-yl group at position 4.
Olanzapine Preparation Products And Raw materials
Raw materials
Tag:Olanzapine(132539-06-1) Related Product Information
Benzodiazepine OLANZAPINE N-OXIDE 2-Ethyl-4-(4-methyl-1-piperazinyl)-7-nitro-10H-thieno(2,3-b)(1,5)benzo diazepine OLANZAPINE-METHYL-D3 GLUCURONIDE OLANZAPINE-METHYL-D3 OLANZAPINE GLUCURONIDE,Olanzapine-b-D-glucuronide Flumezapine Olanzapine Methyl acetate Methyl 1-Methylpiperazine Methyl salicylate 1,2-DIMETHYLHYDRAZINE DIHYDROCHLORIDE Kresoxim-methyl Thiophanate-methyl Methyl bromide Cephalothin Tribenuron methyl