BAMIFYLLINE

BAMIFYLLINE Suppliers list
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427
Email: sales@conier.com
Products Intro: Product Name:7-(2-(ethyl(2-hydroxyethyl)amino)ethyl)-3,7-dihydro-1,3-dimethyl-8-(phenylmethyl)-1h-purine-2,6-dione
CAS:2016-63-9
Purity:99% Package:1kg
Company Name: Coresyn Pharmatech Co., Ltd.
Tel: +86-571-86626709 +86-18157142896
Email: cbc@coresyn.com
Products Intro: Product Name:Bamifylline
CAS:2016-63-9
Purity:NLT 98% Package:1G;1KG;100KG Remarks:CM25687
Company Name: Guangzhou PI PI Biotech Inc  
Tel: 020-81716320 +86-13602409664
Email: Sales@pipitech.com
Products Intro: Product Name:Bamifylline
CAS:2016-63-9
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com Remarks:8’-Benzyl-7-(2-[ethyl(2-hydroxyethyl)amino]ethyl)theophylline
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 821-50328103-801 18930552037
Email: 3bsc@sina.com
Products Intro: Product Name:BaMifylline
CAS:2016-63-9
Purity:98% HPLC Package:1g;5g;25g;100g
Company Name: Sichuan Guanghan Bio-Tech Co., Ltd  
Tel: +86-28-86127071
Email: info@sino-produce.com
Products Intro: Product Name:BAMIFYLLINE
CAS:2016-63-9
Purity:97.00% Package:100g;500g;1kg;10kg;50kg;100kg;1ton
BAMIFYLLINE Basic information
Product Name:BAMIFYLLINE
Synonyms:BAMIFYLLINE;8-BENZYL-7-(2-(HYDROXYETHYL)AMINO)ETHYL)THEOPHYLLINE;8102 CB;8102CB;Bamiphylline;Bax-2739Z;CB-8102;8-benzyl-7-(2-(N-ethyl-2-hydroxyethylamino)ethyl)theophylline
CAS:2016-63-9
MF:C20H27N5O3
MW:385.46
EINECS:
Product Categories:
Mol File:2016-63-9.mol
BAMIFYLLINE Structure
BAMIFYLLINE Chemical Properties
Melting point 80-80.5°
Boiling point 619.0±65.0 °C(Predicted)
density 1.25
storage temp. Hygroscopic, Refrigerator, under inert atmosphere
solubility Chloroform (Very Slightly), DMSO (Slightly), Methanol (Slightly)
pka14.73±0.10(Predicted)
form Solid
color White to Pale Brown
Stability:Hygroscopic
Safety Information
MSDS Information
BAMIFYLLINE Usage And Synthesis
OriginatorBamifylline,ZYF Pharm Chemical
UsesBronchodilator.
UsesBamifylline is a drug of the xanthine chemical class which acts as a selective adenosine A1 receptor antagonist.
DefinitionChEBI: Bamifylline is an oxopurine.
Manufacturing ProcessA mixture of 100 kg of 8-benzyltheophilline, 36 L of N-ethylethanolamine, 300 L of 1,2-dichlorethane and 71 kg of sodium carbonate was refluxed for 24 hours. Then 36 L of N-ethylethanolamine was added and the reaction mixture was refluxed. After cooling to the mixture was added the water and hydrochloric acid. The organic phase was extracted with hydrochloric acid. The acidic phase was neutralized with sodium carbonate and the 7-(N-ethyl-N-β- hydroxyethylaminoethyl)-8-benzyltheophilline was extracted with dichloromethane. The solvent was evaporated and the free base of 7-(N-ethyl- N-β-hydroxyethylaminoethyl)-8-benzyltheophilline was dissolved in methanol. Hydrochloride of 7-(N-ethyl-N-β-hydroxyethylaminoethyl)-8-benzyltheophilline was obtained by addition to the solution the hydrochloric acid; yield 81%, melting point 185-186°C.
Therapeutic FunctionBronchodilator, Coronary vasodilator
BAMIFYLLINE Preparation Products And Raw materials
Raw materialsHydrochloric acid-->2-(Ethylamino)ethanol-->Sodium carbonate
Tag:BAMIFYLLINE(2016-63-9) Related Product Information
Theophylline etamiphyllin BAMIFYLLINE 8-BENZYLTHEOPHYLLINE dimethazan AC 119 1-Methylcaffeine bamifylline hydrochloride ,BAMIFYLLINE HCL 7-(2-aminoethyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione