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Leuprorelin acetate

Leuprorelin acetate Suppliers list
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
Tel: 0755-23311925 18102838259
Email: Abel@chembj.com
Products Intro: Product Name:Leuprorelin acetate
CAS:74381-53-6
Purity:99% Package:2035/G
Company Name: Shenzhen JYMed Technology Co., Ltd.  Gold
Tel:+86 (755) 8635-0931 QQ821653780
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Products Intro:Product Name:Leuprorelin Acetate
CAS:74381-53-6
Purity:98% Package:1.00RMB/1G
Company Name: Hangzhou Peptide Biochem Co.,Ltd  Gold
Tel:86-0571-89197072,18668118770
Email:linda@peptide-manufacturer.com
Products Intro:Product Name:Leuprolide
CAS:74381-53-6
Purity:98.5% Package:1g,10g,25g,100g Remarks:USP,EP
Company Name: Nanjing Leon Biological Technology Co., Ltd.   Gold
Tel:+86 (25) 8452-3390 ex 127
Email:sales@njleonbiotech.com
Products Intro:Product Name:Leuprorelin Acetate
CAS:74381-53-6
Purity:98% HPLC Package:5mg;1G;10G;100G;1KG
Company Name: Shanghai Mokay Pharmaceutical Technology Co., Ltd.  Gold
Tel:021-60257269 18601606476
Email:yl@mkpharma.cn
Products Intro:Product Name:Leuprorelin
CAS:74381-53-6
Purity:98% Package:1g,10g,100g
Leuprorelin acetate Basic information
Anti-cancer drugs
Product Name:Leuprorelin acetate
Synonyms:leutenizinghormone-releasingfactor(pig),6-d-leucine-9-(n-ethyl-l-prolinamid;lupron;tap-144;tap-144-sr;DES-GLY10,[P-LEU6]-LH-RH ETHYLAMIDE;[DES-GLY10, D-LEU6, PRO-NHET9]-LH-RH (HUMAN);(DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR;(DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE
CAS:74381-53-6
MF:C59H84N16O12.C2H4O2
MW:1269.46
EINECS:
Product Categories:Organics;Bases & Related Reagents;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Gonadotropin-releasing hormone (GnRH);Anti-cancer&immunity
Mol File:74381-53-6.mol
Leuprorelin acetate Structure
Leuprorelin acetate Chemical Properties
Melting point 150-155°C
storage temp. −20°C
Merck 14,5457
Safety Information
Safety Statements 22-24/25
WGK Germany 2
RTECS OH6390000
MSDS Information
ProviderLanguage
SigmaAldrich English
Leuprorelin acetate Usage And Synthesis
Anti-cancer drugsLeuprolide acetate is a commonly used hormone anti-cancer drug, , it is a acetate of leuprolide which is a nonapeptide synthetic analogue of LHRH( one kind decapeptide), it is a LH-RH antagonist, LHRH is produced by the hypothalamus, it can promote pituitary for the release of gonadotropins and follicle-stimulating hormone (FSH) and luteinizing hormone (LH). This product’s structure is similar to LHRH, its acting on the anterior pituitary which prompts FSH, LH release function, increases serum concentrations of testosterone and dihydro testosterone. It is used as maintenance therapy for advanced prostate cancer clinically, but in about one week after use of the product, the number of active receptors will be reduced, and gonadotropin secretion will be reduced.After 2 to 4 weeks, the concentration of testosterone and dihydro testosterone can be reduced to castration levels. After the withdrawal, gonadotropin and androgen concentrations can be recovered to normal.
Note that this product is not effective when administered orally, subcutaneous or intramuscular administration has good absorption. T1/2 of parenteral administration is 3 h. There is no accumulation in the body, unchanged drugs and its metabolites in urine excretion rates are2.9% and 1.5%, respectively. Ethanol can enhance the role of this product, the course of treatment should not drink, in case it is difficult to control the incidence of adverse reactions. In the first week of the course of treatment ,patients should try to be hospitalized for monitoring, choose an experienced physician to guide treatment to prevent severe neurological complications, urinary tract obstruction. Injection site should often vary.
The above information is edited by the chemicalbook of Tian Ye.
Chemical PropertiesFluffy Solid
UsesSynthetic nonapeptide agonist analog of LH-RH. Antineoplastic (hormonal).
DefinitionChEBI: An acetate salt obtained by combining the nonapeptide leuprolide with acetic acid. A long lasting GnRH analog, LH-Rh agonist. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant for the t eatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.
Leuprorelin acetate Preparation Products And Raw materials
Tag:Leuprorelin acetate(74381-53-6) Related Product Information
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