ChemicalBook > Product Catalog >Organic Chemistry >Carboxylic acids and derivatives >Carboxylic acid esters and derivatives >Ethyl acetate

Ethyl acetate

Ethyl acetate Suppliers list
Company Name: Shanghai Bojing Chemical Co.,Ltd.
Tel: +86-21-37122233
Email: Candy@bj-chem.com
Products Intro: Product Name:Ethyl acetate
CAS:141-78-6
Purity:99% Package:1kg;25kg;200kg Plastic drum Remarks:Colorless liquid
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:141-78-6
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Shanghai Time Chemicals CO., Ltd.
Tel: +86-021-57951555
Email: jack.li@time-chemicals.com
Products Intro: Product Name:Ethyl acetate
CAS:141-78-6
Company Name: Mainchem Co., Ltd.
Tel: 0592-6210733
Email: sales@mainchem.com
Products Intro: Product Name:Ethyl Acetate
CAS:141-78-6
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: 86-0551-65418684 18949823763
Email: info@tnjchem.com
Products Intro: Product Name:Ethyl acetate
CAS:141-78-6
Purity:99.9% Package:1KG;2USD
Ethyl acetate Basic information
Introduction Solubility in water Purification and water removal methods Uses Production Category Toxicity grading Acute oral toxicity Irritation data Hazardous characteristics of explosive Flammability and hazard characteristics Storage characteristics Extinguishing agent Professional standards
Product Name:Ethyl acetate
Synonyms:AKOS BBS-00004223;ALCOHOL, REAGENT, DENATURED;ALCOHOL;ALCOHOL, DENATURED;ALCOHOL C2;ABSOLUTE ALCOHOL;ACETIC ESTER;ACETIC ETHER
CAS:141-78-6
MF:C4H8O2
MW:88.11
EINECS:205-500-4
Product Categories:Intermediates;Organics;Alcohol;Analytical Chemistry;Solvents for HPLC & Spectrophotometry;Solvents for Spectrophotometry;Aluminum Bottles;ReagentPlus(R)Semi-Bulk Solvents;Ethyl AcetateSolvent Bottles;Spectrophotometric Grade Solvents;Spectrophotometric GradeSolvents;Protein Sequencing;Protein Structural Analysis;Reagents for Protein Sequencing;Chemical Class;EQ - EZAnalytical Standards;EstersAnalytical Standards;Ethyl AcetateSolvents;Biotech SolventsSolvents;CHROMASOLV Solvents (HPLC, LC-MS);CHROMASOLV(R) HPLC Grade SolventsSolvents;Solvents;CHROMASOLV for HPLCSemi-Bulk Solvents;CHROMASOLV(R) for HPLCSolvents;Composite Drums;Drums Product Line;NOWPak(R) Products;ACS Grade SolventsSolvents;ACS GradeSolvents;Analytical Reagents for General Use;E-L, Puriss p.a. ACS;Puriss p.a. ACS;ACS GradeDrums Product Line;Closed Head Drums;Ethyl AcetateSaturated fatty acids and derivatives;Ethyl EsterMore...Close...;ACS GradeSemi-Bulk Solvents;Carbon Steel Flex-Spout Cans;Esters;Capillary GC SolventsSolvent Bottles;GC Capillary;CHROMASOLV(R) LC-MSSolvents;Ethyl AcetateSpectroscopy;LC-MS SolventsProteomics;Solvents and Solutions for Mass Spectrometry;CHROMASOLV LC-MSCHROMASOLV Solvents (HPLC, LC-MS);LC-MS Plus and Gradient;Mass Spectrometry;Mass Spectrometry (MS)&LC-MS;Chromatography/CE Reagents;CHROMASOLV PlusCHROMASOLV Solvents (HPLC, LC-MS);CHROMASOLV(R) PlusSolvents;Amber Glass Bottles;Pesticide Residue Analysis (PRA) SolventsSolvent Bottles;PRA;ACS Grade Solvents;E-H, Puriss p.a.Solvents;Ethyl AcetateChromatography/CE Reagents;Pestanal/Residue Analysis;Puriss p.a.;Solvents - GC/SH;Anhydrous Grade SolventsSolvents;AnhydrousSolvents;Returnable Container Solvents;Ethyl Acetate;Certified Natural ProductsFlavors and Fragrances;E-FSolvents;Ethyl AcetateFlavors and Fragrances;Prepackaged SamplesFlavors and Fragrances;Redi-Pack Bulk;Alphabetical Listings;Flavors and Fragrances;Hematology and Histology;Routine Histology Stains;PVC Coated Bottles;ReagentPlus(R) Solvent Grade ProductsSolvents;ReagentPlus(R)Solvents;Solvent Bottles;Sure/Seal? Bottles;Alpha Sort;E;E-LAlphabetic;EQ - EZ;Volatiles/ Semivolatiles;LEDA HPLC;Ethyl Acetate;Carthamus tinctorius (Safflower oil);Ephedra sinica;Nutrition Research;Panax ginseng;Phytochemicals by Plant (Food/Spice/Herb);Solvent by Type;Zingiber officinale (Ginger);Pharmacopoeia;Pharmacopoeia A-Z;Alphabetical Listings;Certified Food Grade Products;Certified Natural Products;Flavors and Fragrances;Kosher Certified Products;E-F;E-H;Residue Analysis (Japan only);Solvent by Application;Solvents by Special Grades (Japan Customers Only);Aluminum Bottles;Solvent Bottles;Solvent Packaging Options;Amber Glass Bottles;Analytical Reagents;Analytical/Chromatography;CHROMASOLV Plus;Chromatography Reagents &;HPLC &;HPLC Plus Grade Solvents (CHROMASOLV);HPLC/UHPLC Solvents (CHROMASOLV);UHPLC Solvents (CHROMASOLV);ACS and Reagent Grade Solvents;Carbon Steel Flex-Spout Cans;ReagentPlus;ReagentPlus Solvent Grade Products;Semi-Bulk Solvents;Analytical Reagents for General Use;Puriss p.a.;PVC Coated Bottles;Sure/Seal Bottles;Anhydrous;Anhydrous Solvents;Products;Returnable Containers;GC Solvents;Pesticide Residue Analysis (PRA) Solvents;Solvents for GC applications;Solvents for Organic Residue Analysis;Trace Analysis Reagents &;Biotech Solvents;CHROMASOLV for HPLC;Composite Drums;Drums Product Line;HPLC Grade Solvents (CHROMASOLV);NOWPak Products;ACS Grade;ACS Grade Solvents;NULL;Solvent
Mol File:141-78-6.mol
Ethyl acetate Structure
Ethyl acetate Chemical Properties
Melting point −84 °C(lit.)
Boiling point 76.5-77.5 °C(lit.)
density 0.902 g/mL at 25 °C(lit.)
vapor density 3 (20 °C, vs air)
vapor pressure 73 mm Hg ( 20 °C)
refractive index n20/D 1.3720(lit.)
FEMA 2414 | ETHYL ACETATE
Fp 26 °F
storage temp. 2-8°C
solubility Miscible with ethanol, acetone, diethyl ether and benzene.
pka16-18(at 25℃)
form Liquid
color APHA: ≤10
Relative polarity0.228
explosive limit2.2-11.5%, 38°F
Water Solubility 80 g/L (20 ºC)
Merck 14,3757
BRN 506104
Stability:Stable. Incompatible with various plastics, strong oxidizing agents. Highly flammable. Vapour/air mixtures explosive. May be moisture sensitive.
CAS DataBase Reference141-78-6(CAS DataBase Reference)
NIST Chemistry ReferenceEthyl acetate(141-78-6)
EPA Substance Registry SystemAcetic acid ethyl ester(141-78-6)
Safety Information
Hazard Codes F,Xi,Xn,T
Risk Statements 11-36-66-67-20/21/22-10-39/23/24/25-23/24/25-68/20/21/22
Safety Statements 16-26-33-36/37-45-7-25
RIDADR UN 1173 3/PG 2
WGK Germany 1
RTECS AH5425000
1
TSCA Yes
HazardClass 3
PackingGroup II
Hazardous Substances Data141-78-6(Hazardous Substances Data)
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
Ethyl acetate Usage And Synthesis
IntroductionEthyl Acetate is an organic ester compound with a molecular formula of C4H8O2 (commonly abbreviated as EtOAc or EA), appears as a colorless liquid. It is highly miscible with all common organic solvents (alcohols, ketones, glycols, esters), which make it a common solvent for cleaning, paint removal and coatings.
Ethyl acetate is found in alcoholic beverages, cereal crops, radishes, fruit juices, beer, wine, spirits etc. It has a fruity characteristic odor that is commonly recognized in glues, nail polish remover, decaffeinating tea and coffee, and cigarettes. Due to its agreeable aroma and low cost, this chemical is commonly used and manufactured in large scale in the world, as over 1 million tons annually.
Solubility in water8.3 g/100 mL (20 °C)
Purification and water removal methodsEthyl acetate generally has a content of 95% to 98% containing a small amount of water, ethanol and acetic acid. It can be further purified as following: add 100mL of acetic anhydride into 1000mL of ethyl acetate; add 10 drops of concentrated sulfuric acid, heat and reflux for 4h to remove impurities such as ethanol and water, and then further subject to distillation. Distillate is oscillated by 20~30g of anhydrous potassium carbonate and further subject to re-distillation. The product has a boiling point of 77 °C and purity being over 99%.
Uses
Industry Applications Role/Benefit
Flavor and essence Food flavor Used largely to prepare bananas, pears, peaches, pineapple and grape scent food flavors, etc
Alcoholic essence Used slightly as fragrance volatile
Perfume essence Used slightly as fragrance volatile
Chemical manufacture Production of acetamide, acetyl acetate, methyl heptanone, etc Organic chemical raw materials
Production of organic acid Extracting agent
Laboratory Dilution and extraction Supply excellent dissolving capacity
Chromatographic analysis Standard material
Column chromatography and extractions Main component of mobile phase
Reaction solvent Be prone to hydrolysis and transesterification
Chemical analysis Thermometer calibration for sugar separation  Standard material
Determination of bismuth, boron, gold, molybdenum, platinum and thallium Solvent
Entomology Insect collecting and study Used as effective asphyxiant to kill the collected insect quickly without destroying it
Textile industry Cleaning agent Supply excellent dissolving capacity
Printing Flexographic and rotogravure printing Dissolve the resin, control the viscosity and modify the drying rate
Electronics industry Viscosity reducer Reduce the viscosity of resins used in photoresist formulations
Paint manufacture Solvent Dissolve and dilute the paints
Health & personal care products The formulation of nail polish, nail polish removers and other manicuring products Supply excellent dissolving capacity
Pharmaceutical Medicine manufacturing Extraction agent; intermediate
Cosmetics Aroma enhancer In perfume to enhance aroma
Others Tanning extracts Used for desulfurization of tanning, cigarette materials, oil field drilling, metal flotation, descaling, etc
Production of adhesive Solvent
Extract many compounds (phosphorus, cobalt, tungsten, arsenic) from aqueous solution Extracting agent
ProductionIndustrial production of ethyl acetate is mainly classified into three processes.

The first one is a classical Fischer esterification process of ethanol with acetic acid in presence of acid catalyst. This process needs acid catalyst2 such as sulphuric acid, hydrochloride acid, ptoluene sulfonic acid etc. This mixture converts to the ester in about 65% yield at room temperature. 
CH3CH2OH + CH3COOH ↔ CH3COOC2H5 + H2O
The reaction can be accelerated by acid catalysis and the equilibrium can be shifted to the right by removal of water.

The second one is Tishchenko Reaction of acetaldehyde using aluminium triethoxide as a catalyst. In Germany and Japan, most ethyl acetate is produced via the Tishchenko process. 
2 CH3CHO → CH3COOC2H5
This method has been proposed by two different routes; (i) dehydrogenative process, which uses copper or palladium based catalyst and (ii) the oxidative one, which employs, PdO supported catalysts.

The third one, which has been recently commercialized, is addition of acetic acid to ethylene using clay and heteroploy acid7 as a catalyst. 
CH2= CH2 + CH3COOH → CH3COOC2H5 
The processes, however, have some disadvantages; both the conventional esterification and addition of acetic acid to ethylene need stock tanks and apparatus for several feed stocks. Moreover, they use acetic acid that causes apparatus corrosion. Although Teshchenko Reaction uses only one feed and it is a non-corrosive material, it is difficult to handle acetaldehyde because is not available outside of petrochemical industrial area.
In such circumstances, an improved process of ethyl acetate production is strongly desired.
CategoryFlammable liquid
Toxicity gradingpoisoning
UsesPharmaceutic aid (flavor); artificial fruit essences; solvent for nitrocellulose, varnishes, lacquers, and aeroplane dopes; manufacture of smokeless powder, artificial leather, photographic films and plates, artificial silk, perfumes; cleaning textiles, etc.
Acute oral toxicityrat LD50: 5620 mg/kg; Oral-Mouse LD50: 4100 mg/kg
Irritation dataeye-people 400 PPM
Hazardous characteristics of explosiveexplosive when mixed with air
Flammability and hazard characteristicsit is flammable in case of fire, high temperature, and oxidant with burning causing irritated smoke
Storage characteristicsTreasury: ventilation, low-temperature and dry; store it separately from oxidants
Extinguishing agentdry powder, dry sand, carbon dioxide, foam, and 1211 fire extinguishing agent
Professional standardsTWA 1400 mg/m³; STEL 2000 mg/m³
Air & Water ReactionsHighly flammable. Slightly soluble in water. Ethyl acetate is slowly hydrolyzed by moisture.
Reactivity ProfileEthyl acetate is also sensitive to heat. On prolonged storage, materials containing similar functional groups have formed explosive peroxides. Ethyl acetate may ignite or explode with lithium aluminum hydride. Ethyl acetate may also ignite with potassium tert-butoxide. Ethyl acetate is incompatible with nitrates, strong alkalis and strong acids. Ethyl acetate will attack some forms of plastics, rubber and coatings. Ethyl acetate is incompatible with oxidizers such as hydrogen peroxide, nitric acid, perchloric acid and chromium trioxide. Violent reactions occur with chlorosulfonic acid. . SOCl2 reacts with esters, such as Ethyl acetate, forming toxic SO2 gas and water soluble/toxic acyl chlorides, catalyzed by Fe or Zn (Spagnuolo, C.J. et al. 1992. Chemical and Engineering News 70(22):2.).
Health HazardHeadache, irritation of respiratory passages and eyes, dizziness and nausea, weakness, loss of consciousness.
Fire HazardHIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Ethyl acetate Preparation Products And Raw materials
Raw materialsEtanol-->Sulfuric acid -->Acetic acid glacial-->Potassium carbonate-->1-Butanol-->Calcium oxide-->Potassium Acetate-->ketene
Preparation ProductsN-ETHYL 3-NITROBENZENESULFONAMIDE-->Methyl 4-bromo-3-nitrobenzoate-->ETHYL ISONICOTINOYLACETATE-->Sodium 1-heptanesulfonate-->D-glucose pentakis[3,4-dihydroxy-5-[(trihydroxy-3,4,5-benzoyl)oxy]benzoate] -->Ampicillin sodium-->Diphenyl N-cyanocarbonimidate-->4(1H)-Pyrimidinone, 2-methyl- (8CI,9CI)-->4-FLUOROBENZYL ISOCYANATE-->2-(2-FORMYL-PHENOXY)-PROPIONIC ACID-->N-METHOXYCARBONYLMALEIMIDE-->2-Amino-6-bromopyridine-->3-METHYL-4-PYRIDINECARBOXYLIC ACID-->N-BENZYL-6-CHLORO-N-METHYLPYRIDAZIN-3-AMINE-->polyurethane adhesive for dry laminating-->2-ISOCYANATO-4,6-DIMETHOXYPYRIMIDINE-->Methyl 3-bromo-4-methylbenzoate-->N-Acetylethylenediamine-->3-Hydroxypiperidine-->ETHYL PICOLINOYLACETATE-->N-Hexadecyltrimethylammonium chloride-->Boc-O-benzyl-L-tyrosine-->2-Acetylthiazole-->ALUMINUM DI(ISOPROPOXIDE)ACETOACETIC ESTER CHELATE-->Tea polyphenol-->2-(4-Ethoxyphenyl)-2-methylpropanol-->BOC-Glycine-->dry laminating adhesive AD-->adhesive No.1 for shrink packaging-->Triphenylsilanol-->granular adhesive PUA-->special adhesive JA-501 for laminating packaging materials-->special adhesive JA-502 for aluminum-plastics laminating tape-->Enoximone-->coating adhesive tiemao 102-->adhesive M-861 for polyolefin plastics-->self curing adhesive SL-B404-->wealant XY-2-->Water-proof adhesive-->adhesive JX-18-1
Tag:Ethyl acetate(141-78-6) Related Product Information
Megestrol acetate Ethylparaben Ethyl phenylacetate Ethyl acetoacetate Tocopheryl acetate Etanol Glatiramer acetate Vinyl acetate Acetic anhydride ACETATE Sodium acetate Ethyl trifluoroacetate Potassium Acetate Ethyl acetate Ethyl bromoacetate Butyl acetate Methyl acetate Ethyl cyanoacetate