| Company Name: |
Suzhou yacoo science co.,Ltd
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| Tel: |
0512-87182056 18013166090 |
| Email: |
lingling.qi@yacoo.com.cn |
| Products Intro: |
Product Name:Mitoquinone mesylate
CAS:444890-41-9
Purity:98% Package:10g;50g;1kg;5Kg;25kg;
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| Company Name: |
ShangHai Biochempartner Co.,Ltd
|
| Tel: |
17754423994 17754423994 |
| Email: |
2853530910@QQ.com |
| Products Intro: |
Product Name:Mitoquinone
CAS:444890-41-9
Purity:98% HPLC LCMS Package:100MG;1G
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| Product Name: | MITOQ | | Synonyms: | Mitoquinol(MITOQ);MitoQ10;Mitoquinone
Discontinued;Mitoquinone | Mitochondria-targeted antioxidant;Mitoquinone (Mito-Q | | CAS: | 444890-41-9 | | MF: | C37H44O4P+ | | MW: | 583.73 | | EINECS: | | | Product Categories: | | | Mol File: | 444890-41-9.mol |  |
| | MITOQ Chemical Properties |
| storage temp. | -20° | | solubility | Soluble in DMSO (70 mg/mL); ethanol (30 mg/mL) | | form | waxy solid | | color | Brown | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| | MITOQ Usage And Synthesis |
| Description | Mitoquinone (444890-40-9) is a mitochondria-targeted antioxidant. Displays cardio- and neuroprotective effects.1?Displays beneficial effects in mouse models of Alzheimer’s disease.2?Mitoquinone protects pancreatic β-cells against oxidative stress and improves insulin secretion.3 Cell permeable.? Mesylate salt (Cat# 10-3914)and mesylate cyclodextrin complex (Cat# 10-3915) are also available. | | Uses | Mitoquinone is a mitochondria-targeted antioxidant. | | References | 1) Ghosh et al. (2010), Neuroprotection by a mitochondria-targeted drug in a Parkinson’s disease model; Free Radic. Biol. Med., 49 1674
2) McManus et al. (2011), The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease; J. Neurosci., 31 15703
3) Lim et al. (2011), Mitochondria-targeted antioxidants protect pancreatic β-cells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity; Cell Physiol. Biochem., 28 873
4) Demers-Lamarche et al. (2016) Loss of Mitochondrial Function Impairs Lysosomes; J. Biol. Chem. 291 10263 [Focus Citation]
5) Zhou et al. (2018) Mitochondrial-targeted antioxidant MitoQ provides neuroprotection and reduces neuronal apoptosis in experimental traumatic brain injury possibly via the Nrf2-ARE pathway; Am. J. Transl. Res., 10 1887 [Focus Citation]
6) Xiao et al. (2017) The mitochondrial-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1; Redox Biol., 11 297 [Focus Citation]
7) Deng et al. (2019), Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule; J. Clin. Invest., 129 5033 [Focus Citation] |
| | MITOQ Preparation Products And Raw materials |
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