卡那霉素 B
| 中文名称 | 卡那霉素 B |
|---|---|
| 中文同义词 | 卡那霉素B;卡那霉素 B?, >98%;妥布霉素EP杂质A;卡那霉素杂质B;(2R,3S,4R,5R,6R)-5-氨基-2-(氨基甲基)-6-(((1R,2S,3S,4R,6S)-4,6-二氨基-3-(((2S ,3R,4S,5S,6R)-4-氨基-3,5-二羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-2-羟基环己基)氧基)四氢-2H-吡喃- 3,4-二醇;妥布霉素 EPA;卡那霉素杂质3;卡那霉素B对照品 |
| 英文名称 | Bekanamycin |
| 英文同义词 | d-streptamine,o-3-amino-3-deoxy-alpha-d-glucopyranosyl-(1-4)-o-(2,6-diamino-2,;kanendomycin;kdm;nebramycinfactor5;nebramycinv;(2R,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4-diol;Bekanamycin;NK 1006 |
| CAS号 | 4696-76-8 |
| 分子式 | C18H37N5O10 |
| 分子量 | 483.51 |
| EINECS号 | 225-170-5 |
| 相关类别 | 小分子抑制剂，天然产物;其他原料;Inhibitors;Pharmaceutical Intermediates;API |
| Mol文件 | 4696-76-8.mol |
| 结构式 |  |
卡那霉素 B 性质
| 熔点 | 178-182° (dec) |
|---|---|
| 比旋光度 | D18 +130° (c = 0.5 in water); D21 +114° (c = 0.98 in water) |
| 沸点 | 580.49°C (rough estimate) |
| 密度 | 1.3771 (rough estimate) |
| 折射率 | 1.7600 (estimate) |
| 储存条件 | under inert gas (nitrogen or Argon) at 2–8 °C |
| 溶解度 | 酸水溶液（微溶）、甲醇（微溶、加热、超声处理） |
| 形态 | 固体 |
| 酸度系数(pKa) | 13.07±0.70(Predicted) |
| 颜色 | 晶体 |
| 稳定性 | 吸湿性 |
Bekanamycin (Kanamycin B) is a precursor for semisynthetic antibiotics such as Arbekacin and Dibekacin and is generally extracted from the broth of
S. kanamyceticus
.
Bekanamycin (Kanamycin B) in a concentration-dependent fashion reduces reversibly the quantal content of the end-plate potentials while it has no observable effect on the configuration of the extracellularly recorded presynaptic action potential. The reduction in evoked transmitter release produced by Bekanamycin could be antagonized either by increasing the external calcium concentration or by drugs like the aminopyridines which are to greatly enhance transmitter release from motor nerve terminals. Bekanamycin exerts potent inhibitory effects on transmitter release probably by interfering with the influx of calcium that occurs during depolarization of motor nerve terminals.
安全信息
| 毒性 | LD50 i.v. in mice: 136 mg/kg (Wakazawa) |
|---|