苯赖加压素
中文名称 | 苯赖加压素 |
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中文同义词 | 苯赖加压素;2-苯丙氨酸-8-赖氨酸加压素;醋酸苯赖加压素;苯赖加压素 FELYPRESSIN;苯赖加压素 EP标准品;PLV-2 ACETATE;FELYPRESSIN游离态 |
英文名称 | Felypressin |
英文同义词 | FELYPRESSIN;H-CYS-PHE-PHE-GLN-ASN-CYS-PRO-LYS-GLY-NH2, CYS1,6, CYCLIC;[PHE2,LYS8]-VASOPRESSIN;2-L-Phenylalanine-8-L-lysine-vasopressin;N-[5-Amino-1-(carbamoylmethylcarbamoyl)pentyl]-1-[19-amino-13,16-dibenzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide;Octapressin;Phelypressin;PLV-2 |
CAS号 | 56-59-7 |
分子式 | C46H65N13O11S2 |
分子量 | 1040.22 |
EINECS号 | 200-282-7 |
相关类别 | 多肽及蛋白质类;加压素及其衍生物;生物化学品;多肽;小分子抑制剂;小分子抑制剂,天然产物;多肽中间体;Vasopressin and Oxytocin receptor;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors;医药原料药;药物肽,定制肽,美容肽,CRO&CMO;药物多肽 |
Mol文件 | 56-59-7.mol |
结构式 |
苯赖加压素 性质
熔点 | >197oC (dec.) |
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沸点 | 1571.3±65.0 °C(Predicted) |
密度 | 1.288±0.06 g/cm3(Predicted) |
储存条件 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
溶解度 | 易溶于水,几乎不溶于丙酮和乙醇(96%)。溶于碱金属氢氧化物的稀溶液。 |
酸度系数(pKa) | 12.82±0.70(Predicted) |
形态 | 固体 |
颜色 | 白色 |
序列 | H-[Cys-Phe-Phe-Gln-Asn-Cys]-Pro-Lys-Gly-NH2,(Disulfide bridge: Cys-Cys) |
CAS 数据库 | 56-59-7(CAS DataBase Reference) |
Vasopressin 1
Felypressin is a synthetic hormone of the posterior pituitary lobe characterized by vasoconstrictor properties that is widely used in dental procedures. The vasoconstrictor action of Felypressin seems to be mediated by V1 receptors of the blood vessel smooth muscle cells.
Felypressin can reduce toxicity during dental procedures. Felypressin increases the diastolic blood pressure of hypertensive patients with controlled blood pressure.
Cardiovascular effects of Felypressin (240 ng/kg; intravenous injection) are studied in Wistar rats. Felypressin induces a pressor effect. Felypressin depends on V1 receptors to induce pressor and bradycardic effects, and that it produces a high relationship between bradycardia and mean arterial pressure variation depending on area postrema and central V1 receptors.
单杂≤1.0%
醋酸根含量5.0%~12.0%
水分含量≤10.0%
肽含量≥80.0%
不良反应和禁忌:用药后可有面色和皮肤苍白、尿意、腹痛、腹泻、脉搏减慢等症状;过量会恶心、呕吐。冠状动脉患者忌用,孕妇和老人慎用。
安全信息
WGK Germany | 3 |
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