- Quinapril hydrochloride
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- $19.00 / 1KG
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2022-02-25
- CAS:82586-55-8
- Min. Order: 1Kg/Bag
- Purity: 99%
- Supply Ability: 20tons
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| | Quinapril hydrochloride Basic information |
| | Quinapril hydrochloride Chemical Properties |
| Melting point | 120-130°C | | alpha | D23 +14.5° (c = 1.2 in ethanol) (Klutchko); D25 +15.4° (c = 2 in methanol) (Goel, Krolls) | | storage temp. | 2-8°C | | solubility | H2O: >10mg/mL | | form | solid | | color | white | | CAS DataBase Reference | 82586-55-8(CAS DataBase Reference) |
| Safety Statements | 22-24/25 | | WGK Germany | 2 | | RTECS | NW7176000 | | HS Code | 2933492250 | | Hazardous Substances Data | 82586-55-8(Hazardous Substances Data) | | Toxicity | Freely sol in aq solvents. LD50 in male, female mice, rats (mg/kg): 1739, 1840, 4280, 3541 orally; 504, 523, 158, 107 i.v. (Kaplan, 1989) |
| | Quinapril hydrochloride Usage And Synthesis |
| Chemical Properties | White Crystalline Solid | | Uses | Quinapril hydrochloride has been used as an angiotensin-converting enzyme (ACE) inhibitor to study its effects on renal tubular epithelial cell proliferation in human renal tubular epithelial cells. It has also been used as an ACE inhibitor to evaluate its effects on the expression of angiotensin II (AII) in patient-derived Atheroma samples. | | Uses | Antihypertensive;Dopamine receptor agonist | | Uses | Quinapril is an angiotensin converting enzyme (ACE) inhibitor. Antihypertensive. | | Definition | ChEBI: Quinapril hydrochloride is a hydrochloride resulting from the reaction of equimolar amounts of quinapril and hydrogen chloride. A prodrug for quinaprilat hydrochloride (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) for the treatment of hypertension and congestive heart failure. It has a role as an antihypertensive agent and an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. It contains a quinapril(1+). | | Brand name | Accupril (Pfizer); Quinapril (Lupin); Quinapril (Ranbaxy)
. | | General Description | Quinapril hydrochloride,(S)-[(S)-N-[(S)21-carboxy3-phenylpropyl]alanyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid 1-ethyl ester hydrochloride(Acuretic), forms the diacid quinaprilate in thebody. It is more potent than captopril and equipotent to theactive form of enalapril. | | Biochem/physiol Actions | Quinapril is a short-acting angiotensin converting enzyme (ACE) inhibitor. |
| | Quinapril hydrochloride Preparation Products And Raw materials |
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