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Axitinib

Axitinib Suppliers list
Company Name: Nanjing Gold Pharmaceutical Technology Co. Ltd.
Tel: 025-84209270 15906146951
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Products Intro: Product Name:Axitinib
CAS:319460-85-0
Purity:99% Package:50KG;25KG;10KG;5KG;1KG
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Products Intro: Product Name:Axitinib
CAS:319460-85-0
Purity:99% Package:117000/KG
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Products Intro:Product Name:Axitinib
CAS:319460-85-0
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Company Name: Shanghai Scientia Pharmaceutical Technology Co., Ltd.  Gold
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Products Intro:Product Name:Axitinib
CAS:319460-85-0
Purity:99% Package:1.00RMB/1KG
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Products Intro:Product Name:Axitinib
CAS:319460-85-0
Purity:99% Package:10mg;50mg;100mg;250mg
Axitinib Basic information
FDA approved axitinib use of treating advanced kidney cancer
Product Name:Axitinib
Synonyms:Axitinib (usan);D03218;Axitinib(AG 013736);Axtinib;N-Methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzaMide;Inlyta;10mg;Axitinib (TINIBS)
CAS:319460-85-0
MF:C22H18N4OS
MW:386.47
EINECS:
Product Categories:Pharmaceuticals;Protein Kinase Inhibitors and Activators;Pfizer compounds;API;AG 013736;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals
Mol File:319460-85-0.mol
Axitinib Structure
Axitinib Chemical Properties
Melting point 213-215°C
density 1.4
storage temp. -20°C Freezer
solubility DMSO: ≥8mg/mL
color white to tan
CAS DataBase Reference319460-85-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,N
Risk Statements 22-50/53
Safety Statements 60-61
RIDADR UN 3077 9 / PGIII
MSDS Information
Axitinib Usage And Synthesis
FDA approved axitinib use of treating advanced kidney cancerJanuary 27, 2012, the FDA approved axitinib for the treatment of advanced kidney cancer (renal cell carcinoma) which other drugs unanswer . Inlyta is manufactured and sold by Pfizer,and is a oral pill taken twice a day.
Renal cell carcinoma is a type of tumor originating from the tubular endothelial cells. Axitinib can prevent certain protein called kinases playing a role in tumor growth and metastasis .
Axitinib is a small molecule tyrosine kinase inhibitor, effective against multiple targets, including VEGF receptors 1, 2 and 3.
Dr. Richard Pazdur, hematology and oncology drugs office director of FDA Drug Evaluation and Research Centre, said: "This is the seven kind of drugs allowed treating metastatic or advanced renal cell carcinoma since 2005 . Overall, during this time ,record level of drug development has dramatically changed the treatment of metastatic renal cell carcinoma paradigm, and offers a variety of treatment options for patients. "
In recent years, the drug has been approved for the treatment of kidney cancer include sorafenib (2005), sunitinib (2006), temsirolimus(2007), everolimus (2009), bevacizumab(2009) and pazopanib(2009).
The above information is edited by the chemicalbook of Tian Ye.
Chemical PropertiesOff-White Solid
UsesA tyrosine kinase inhibitor; used in cancer therapy.
UsesAxitinib (AG-013736) is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively.
UsesAxitinib is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively.
UsesAxitinib is a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.
Axitinib Preparation Products And Raw materials
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