- Enclomiphene
-
- $250.00 / 10g
-
2024-04-29
- CAS:15690-57-0
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 10kg
- TRANS-CLOMIPHENE HCL
-
- $0.00 / 1kg
-
2023-11-27
- CAS:15690-57-0
- Min. Order: 1kg
- Purity: 99% HPLC
- Supply Ability: 20 tons
|
| | Enclomiphene Basic information |
| Product Name: | Enclomiphene | | Synonyms: | 2-diphenylethenyl)phenoxy)-n,n-diethyl-2-(4-(2-chloro-(e)-ethanamin;2-diphenylvinyl)phenoxy)-2-(p-(2-chloro-(e)-triethylamin;ici46476;trans-2-(p-(2-chloro-1,2-diphenylvinyl)phenoxy)triethylamine;trans-clomifene;trans-clomiphene;TRANS-CLOMIPHENE HCL;RMI 16,289 | | CAS: | 15690-57-0 | | MF: | C26H28ClNO | | MW: | 405.96 | | EINECS: | 213-008-6 | | Product Categories: | 15690-57-0 | | Mol File: | 15690-57-0.mol |  |
| | Enclomiphene Chemical Properties |
| Melting point | 149.0-150.5° | | Boiling point | 509.0±50.0 °C(Predicted) | | density | 1.104±0.06 g/cm3(Predicted) | | pka | 9.60±0.25(Predicted) |
| | Enclomiphene Usage And Synthesis |
| Description | Enclomiphene is a synthetic and nonsteroidal antiestrogen. It is the more potent isomer and the one responsible for its ovulation-inducing actions. The half-life of enclomiphene is relatively short, so serum concentrations rise and fall quickly during and after treatment. Antiestrogens represent the first-line treatment strategy in WHO class-2 anovulatory infertility. | | Uses | trans-Clomiphene is a Clomiphene (C587025) stereoisomer, a synthetic estrogen agonist-antagonist. Gonad-stimulating principle. Treatment for infertility. | | Definition | ChEBI: Clomiphene is a tertiary amine. It has a role as an estrogen antagonist and an estrogen receptor modulator. It derives from a hydride of a stilbene. | | Preparation | CONDENSATION OF 4-HYDROXYBENZOPHENONE WITH 2-(DIETHYLAMINO)ETHYL CHLORIDE FOLLOWED BY TREATMENT WITH BENZYL MAGNESIUM CHLORIDE AND DEHYDRATION TO GIVE 2-(P-(1,2-DIPHENYLVINYL)PHENOXY)TRIETHYLAMINE WHICH IS CHLORINATED AND TREATED WITH CITRIC ACID /CITRATE/ | | Biological Activity | Enclomiphene is the trans-isomer of clomiphene citrate (CC). It has a higher rate of clearance and is less active than the cis-isomer, cis-clomiphene. Clomiphene citrate has been evaluated for antineoplastic activity against breast cancer. | | Mode of action | Enclomiphene is a non-steroidal estrogen receptor antagonist that promotes gonadotropin-dependent testosterone secretion by the testes. The main mechanism of its action is thought to be its antagonistic effects on the hypothalamic-pituitary axis and stimulation of GnRH secretion. | | References | [1] SIMON HILL Richard Q Vijayaraman Arutchelvam. Enclomiphene, an estrogen receptor antagonist for the treatment of testosterone deficiency in men.[J]. Idrugs, 2009, 12 2: 109-119.
[2] KATHERINE M RODRIGUEZ Larry I L Alexander W Pastuszak. Enclomiphene citrate for the treatment of secondary male hypogonadism.[J]. Expert Opinion on Pharmacotherapy, 2016, 17 11: 1561-1567. DOI:10.1080/14656566.2016.1204294.
[3] JOSHUA A EARL Edward D K. Enclomiphene citrate: A treatment that maintains fertility in men with secondary hypogonadism.[J]. Expert Review of Endocrinology & Metabolism, 2019, 14 3: 157-165. DOI:10.1080/17446651.2019.1612239. |
| | Enclomiphene Preparation Products And Raw materials |
|