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| 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol Basic information |
Product Name: | 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol | Synonyms: | 1H-Pyrrolo[2,3-b]pyridin-5-ol, 1-[tris(1-methylethyl)silyl]-;1-[Tris(1-methylethyl)silyl]-1H-pyrrolo[2,3-b]pyridin-5-ol;1-triisopropylsilylpyrrolo[2,3-b]pyridin-5-ol;1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-4-sulfonic acid;1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridin-5-ol;1-tri(propan-2-yl)silylpyrrolo[2,3-b]pyridin-5-ol;1-Triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-5-ol;1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol | CAS: | 685514-01-6 | MF: | C16H26N2OSi | MW: | 290.48 | EINECS: | | Product Categories: | | Mol File: | 685514-01-6.mol | |
| 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol Chemical Properties |
Boiling point | 341.6±35.0 °C(Predicted) | density | 1.03±0.1 g/cm3(Predicted) | pka | 8.50±0.40(Predicted) |
| 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol Usage And Synthesis |
Synthesis | Add 10.8g (34mmol) of (1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)boronic acid and 120mL of tetrahydrofuran to a round bottom flask equipped with a magnetic stirrer, an inert gas source and a separating funnel, and stir to dissolve; Add 34mL of 1mol/L sodium hydroxide solution and 4.60g (40.6mmol) of 30% hydrogen peroxide dropwise at 0°C. After the addition, React at 0°C for 1 hour and detect the reaction by TLC. Add 4.8g (20.24mmol) of sodium thiosulfate, adjust to pH=5 with 2mol/L hydrochloric acid, extract with ethyl acetate (2x200mL), combine the organic phases, wash with saturated brine in turn, dry with a sodium sulfate, and reduce Concentrate under pressure. The residue was purified by silica gel column chromatography [eluent: dichloromethane] to obtain 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol 9.4g, yield 95.0%.
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| 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol Preparation Products And Raw materials |
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