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ABT-199

ABT-199 Suppliers list
Company Name: Chengdu Henghui Pharm Tec Co. Ltd.
Tel: 13540674322 15828370308,QQ:2879822141
Email: service@2hpharm.com
Products Intro: Product Name:Venetoclax (ABT-199)
CAS:1257044-40-8
Purity:≥99% by HPLC Package:1g 5g 10g 25g 50g 100g Remarks:brand: 2hpharm | product NO.:HH17004 | purity: ≥98% by HPLC.Target:Bcl-2 family
Company Name: Chengdu Henghui Pharmaceutical Co., Ltd.
Tel: 86-028-89481236 13540674322
Email: 2879822141@qq.com
Products Intro: Product Name:Venetoclax; ABT-199
CAS:1257044-40-8
Purity:>=99% by HPLC Package:1g 5g 10g 25g 50g 100g 500g 1kg Remarks:brand:2hpharm | product NO.HH17004| purity:>=99%
Company Name: Nanjing Gold Pharmaceutical Technology Co. Ltd.
Tel: 025-84209270 15906146951
Email: wgp@nanjing-pharmaceutical.com
Products Intro: Product Name:ABT-199
CAS:1257044-40-8
Purity:99% Package:50KG;25KG;10KG;5KG;1KG
Company Name: Hui Chem Co., Ltd.  Gold
Tel:(+86) 21 3479 9779
Email:info@huichem.com
Products Intro:Product Name:ABT-199
CAS:1257044-40-8
Purity:>99% Package:1g;10g;100g
Company Name: SPIRO PHARMA  Gold
Tel:-
Email:eric_feng1954@126.com
Products Intro:Product Name:ABT-199
CAS:1257044-40-8
Purity:95% -98%HPLC Package:1GR;10GR;50GR;100GR;250GR;500GR;1KG;5KG;10KG;100KG
ABT-199 Basic information
Description References
Product Name:ABT-199
Synonyms:ABT-199;ABT199,GDC0199;GDC 0199;GDC0199;GDC-0199;4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-benzamide;Benzamide, 4-[4-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-;4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-benzamide ABT-199 (GDC-0199)
CAS:1257044-40-8
MF:C45H50ClN7O7S
MW:868.4392
EINECS:-0
Product Categories:Apis;Inhibitor;Inhibitors
Mol File:1257044-40-8.mol
ABT-199 Structure
ABT-199 Chemical Properties
Safety Information
MSDS Information
ABT-199 Usage And Synthesis
DescriptionABT-199, also known as venetoclax, is a small, oral chemical molecule used for the treatment of chronic lymphocytic leukemia (CLL) associated with a specific chromosomal abnormality. As a second line treatment drug of CLL, ABT-199 take effects through acting as a BH3-mimetic and inhibitor of Bcl-2 (the anti-apoptotic B-cell lymphoma-2protein), further inducing apoptosis of CLL cells but not platelets. It also has the potential for the treatment of ER-positive breast cancer.
Referenceshttps://en.wikipedia.org/wiki/Venetoclax
Vogler, M, et al. "ABT-199 selectively inhibits BCL2 but not BCL2L1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets." British Journal of Haematology 163.1(2013):139-42.
Vaillant, François, et al. "Targeting BCL-2 with the BH3 Mimetic ABT-199 in Estrogen Receptor-Positive Breast Cancer." Cancer Cell 24.1(2013):120-9.
Lindeman, G. J., et al. "Abstract P2-09-01: Targeting BCL-2 with the BH3 mimetic ABT-199 in ER-positive breast cancer." Cancer Research 73.24 Supplement (2013):P2-09-01-P2-09-01.
DefinitionChEBI: A member of the class of pyrrolopyridines that is a potent inhibitor of the antiapoptotic protein B-cell lymphoma 2. It is used for treamtment of chronic lymphocytic leukemia with 17p deletion.
ABT-199 Preparation Products And Raw materials
Tag:ABT-199(1257044-40-8) Related Product Information
2-[(1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy]-4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl]methyl]piperazin-1-yl]benzoic acid 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine 1H-Pyrrolo[2,3-b]pyridin-5-ol, 1-[tris(1-methylethyl)silyl]- abt199 int 2 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide 4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde Vipadenant 2-(3-fluorophenyl)-3-methylmorpholine(3-fluorophenmetrazine)(3-FPM) AZD-9291 (Mesylate) N-[1-(Aminocarbonyl)-2,2-dimethylpropyl]-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide 1-Propanone, 1-(4-ethylphenyl)-2-(MethylaMino)- THJ-018 Bortezomib ABT 737 Trametinib (GSK1120212) ABT 263 Ibrutinib Olaparib