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Tenofovir

Tenofovir Suppliers list
Company Name: Nanjing Gold Pharmaceutical Technology Co. Ltd.
Tel: 025-84209270 15906146951
Email: wgp@nanjing-pharmaceutical.com
Products Intro: Product Name:Tenofovir
CAS:147127-20-6
Purity:99% Package:50KG;25KG;10KG;5KG;1KG
Company Name: Capot Chemical Co.,Ltd.
Tel: +86 (0)571-855 867 18
Email: sales@capotchem.com
Products Intro: Product Name:Tenofovir
CAS:147127-20-6
Purity:98% Min. Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
Tel: 0755-23311925 18102838259
Email: Abel@chembj.com
Products Intro: Product Name:Tenofovir
CAS:147127-20-6
Purity:99% Package:880/KG
Company Name: Beijing Zhongshuo Pharmaceutical Technology Development Co., Ltd  Gold
Tel:010-64430626/13801208576
Email:maggie@chinazhongshuo.com
Products Intro:Product Name:1-(6-Aminopurin-9-yl)propan-2-yloxymethylphosphonic acid
CAS:147127-20-6
Purity:99%
Company Name: T&W GROUP  Gold
Tel:+86-21-61551611, 61551462, 61551420, 61551610
Email:contact@trustwe.com
Products Intro:Product Name:Tenofovir
CAS:147127-20-6
Purity:98% Package:100g;500g;1kg;5kg;10kg
Tenofovir Basic information
Indications and Usage Mechanisms of Action Pharmacokinetics Adverse Effects
Product Name:Tenofovir
Synonyms:1-(6-aminopurin-9-yl)propan-2-yloxymethylphosphonic acid;D,L-TENOFOVIR;TENOFOVIR;(R)-9-(2-PHOSPHONYLMETHOXYPROPYL)-ADENINE;(R)-9-(2-Phosphonomethoxypropyl)Adenine;Tenofovir(ForResearchOnly);(R)-PMPA;[[(1R)-2(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic Acid
CAS:147127-20-6
MF:C9H14N5O4P
MW:287.21
EINECS:
Product Categories:Purine;ACTIVE PHARMACEUTICAL INGREDIENTS;Nucleotides and Nucleosides;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Phosphorylating and Phosphitylating Agents;Inhibitors
Mol File:147127-20-6.mol
Tenofovir Structure
Tenofovir Chemical Properties
Melting point 276-280°C
storage temp. Store at -20°C
Water Solubility 13.4 mg/mL (25 ºC)
CAS DataBase Reference147127-20-6(CAS DataBase Reference)
Safety Information
MSDS Information
Tenofovir Usage And Synthesis
Indications and UsageTenofovir disoproxil (Viread) is the first nucleotide analogue approved by the American FDA to treat HIV-1 infections. Tenofovir disoproxil is a drug used in the AIDS cocktail treatment method, and research shows that it has the ability to increase monkeys’ immunity to immunodeficiency viruses (similar to the human AIDS virus). Tenofovir disoproxil is used in combination with other reverse transcriptase inhibitors to treat HIV-1 infections and hepatitis B.
Mechanisms of ActionTenofovir disoproxil is an acyclic nucleoside antivirus drug and has an inhibiting effect on HBV multi-enzyme complexes and HIV reverse transcriptase. Its active content tenofovir phosphonate directly competitively binds to natural deoxyribose substrate to inhibit the virus multi-enzyme complex and inserts itself into the DNA to end the nucleotide chain. Tenofovir disoproxil is barely absorbed by the gastrointestinal duct, so it undergoes esterification and ionization to become tenofovir ester fumarate. Tenofovir is soluble in water and can be quickly absorbed and decomposed into the active substance tenofovir, which then transforms into the active metabolite tenofovir phosphonate. As this drug is not metabolized by the CYP450 enzyme system, it has a very low chance of drug interactions caused by this enzyme.
PharmacokineticsTenofovir disoproxil reaches peak blood concentration 1-2 hours after intake. Tenofovir disoproxil’s bioavailability increases by about 40% when taken with food. The intracellular half-life of tenofovir phosphonate is about 10 hours, so doses can be taken once daily. This drug is mainly filtered through renal glomeruli and excreted through the renal tubule transport system, with 70-80% excreted in its original form through urine.
Adverse Effects
  • Weakness and exhaustion.
  • Mild to moderate gastrointestinal reactions, including diarrhea, stomach pain, nausea, vomiting, bloating, lactic acid poisoning, hepatomegaly and fatty liver, and pancreatitis. These adverse reactions also commonly appear individually or combined when taking nucleoside analogues.
  • Metabolic system hypophosphatemia (1% occurrence rate).
  • Fat accumulation and redistribution, including centripetal obesity, buffalo hump, thin limbs, breast growth, and Cushing syndrome.
  • May cause lactic acid poisoning, hepatomegaly related to steatosis, etc.
  • Effects on nervous system: dizziness and headache.
  • Effects on respiratory system: difficulty breathing.
  • Effects on skin: drug rash.
Chemical PropertiesWhite Crystalline Solid
UsesAcyclic phosphonate nucleotide analogue. Used as an anti-HIV agent
UsesAcyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.
UsesTenofovir blocks reverse transcriptase and hepatitis B virus infections.
DefinitionChEBI: A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxy ethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.
Biological ActivitySelectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase). Prevents cytotoxicity in SIV-infected C-8166 cells in vitro (IC 50 = 1.5 μ M). Antiviral agent.
Tenofovir Preparation Products And Raw materials
Tag:Tenofovir(147127-20-6) Related Product Information
Chloromethyl isopropyl carbonate Diethyl (tosyloxy)methylphosphonate CHLOROMETHYL CHLOROFORMATE (JMC)(INTERMEDIATE OF TENOFOVIR DISOPROXIL FUMARATE) TENOFOVIR MONOPHOSPHATE TENOFOVIR, [8-14C]- TENOFOVIR DIPHOSPHATE Tenofovir Phosphate, >60% Intermediate For Tenofovir Tenofovir Adefovir PROPANE Tenofovir disoproxil Guaiacol Anisole ISOPROPYLPHENYLDIPHENYL PHOSPHATE Adenine (Trifluoromethoxy)benzene 4-Methoxyphenol