ChemicalBook > Product Catalog >API >Anesthetic Agents >Local anesthetics >Prilocaine

Prilocaine

Prilocaine Suppliers list
Company Name:Jinan Ruixing Pharmaceutical technology Co., Ltd.  Gold
Tel:+86-531-88895311 88883606 18653121093
Email:sales@jnrxchem.com
Company Name:Anhui Dexinjia Biopharm Co., Ltd  Gold
Tel:+86 (531)82375831; 82375879 , 82375892, 82375809
Email:1074800342@qq.com
Company Name:Jinan Jianfeng Chemical Co., Ltd.   Gold
Tel:0531-88110457 83130510 83130502
Email:info@pharmachemm.com
Company Name:Guangzhou Kafen Biotech Co.,Ltd  Gold
Tel:020-31121484 18027468163
Email:gy@yccreate.com
Company Name:Shenzhen Sendi Biological Technology Co., Ltd.  Gold
Tel:0755-23574479 手机/微信:18124570582 QQ:2355327139
Email:siliao02@yccreate.com
Prilocaine Basic information
Local anesthetic drug Chemical Properties Uses Production method
Product Name:Prilocaine
Synonyms:2-(propylamino)-o-propionotoluidid;2-(Propylamino)-o-propionotoluidide;2-Methyl-alpha-propylaminopropionanilide;alpha-n-Propyl-amino-2-methylpropionanilide;alpha-n-propylamino-2-methylpropionanilide;Astra 1512;Astra 1515;astra1512
CAS:721-50-6
MF:C13H20N2O
MW:220.31
EINECS:211-957-0
Product Categories:Active Pharmaceutical Ingredients;Inhibitors
Mol File:721-50-6.mol
Prilocaine Structure
Prilocaine Chemical Properties
CAS DataBase Reference721-50-6(CAS DataBase Reference)
NIST Chemistry ReferencePropanamide, n-(2-methylphenyl)-2-(propylamino)-(721-50-6)
Safety Information
Hazardous Substances Data721-50-6(Hazardous Substances Data)
MSDS Information
Prilocaine Usage And Synthesis
Local anesthetic drugPrilocaine belongs to amide local anesthetic drug with its anesthesia intensity and speed being similar as lidocaine but with a longer duration period and weaker effect on vasodilation. It has a lower toxicity than lidocaine. It is clinically for local anesthesia, especially suitable for treating patients who are not allowed to use adrenaline.
[Pharmacological] its 3% solution has a similar local anesthesia efficacy as the anesthesia drug of 2% lidocaine together with adrenaline. It has a slow onset time which lasts about 6 ~ 7min and the duration time of about 1.5 ~ 2h. It has a strong penetration capability through mucous membranes. Adrenaline has a slightly prolonged duration of action. PPB is 55% and T1/2 of about 1.5h. It is subject to liver metabolism with its metabolites nitroso toluidine being able to oxidize hemoglobin to form methemoglobin. It can be transported to the fetus through the placenta.
[Adverse reactions] once the usage amount exceeds 600mg, methaemoglobinaemia can occur with cyanosis, tachycardia, headache, dizziness and weakness occurring.
[Note] patients of anemia, congenital or acquired methaemoglobinaemia, respiratory failure or heart failure and hypoxic patients should be disabled. It is forbidden for applied to obstetric anesthesia.
[Usage and dosage] infiltration anesthesia: 0.5% to 1% solution with the duration of action of 1 to 1.5 hours.
Nerve blocking anesthesia: use 1% to 2% solution with the duration of action being 2-3 hours.
Epidural anesthesia: use10 to 30 mL of 1.5% ~ 1% solution with the duration of action of 2.5 to 3.5 hours. Use a maximum dose of 600 mg.
the structural formula of prilocaine
Figure 1 the structural formula of prilocaine
The above information is edited by the Chemicalbook of Dai Xiongfeng.
Chemical PropertiesIt is a kind of needle-like crystals with the melting point being 37-38 ℃ and the boiling point being 159-162 ℃ (0.133kPa), and refractive index (nD20) being 1.5299. Its hydrochloride ([1786-81-8]) is a white crystalline powder. The Melting point is 167-168 ℃. It is soluble in water and ethanol, slightly soluble in chloroform. It has sour taste and bitter taste and is odorless.
UsesIt is a kind of local anesthetic drug. The product has better efficacy than procaine and the local anesthesia intensity and speed being similar as lidocaine but with longer duration time and less toxicity as well as smaller accumulation effect. It is suitable for epidural anesthesia, conduction anesthesia and infiltration anesthesia.
Production methodO-toluidine and α- bromo-propionyl bromide are condensed and further have reaction with propylamine obtain prilocaine.
Prilocaine Preparation Products And Raw materials
Raw materialso-Toluidine-->Propylamine-->Propionyl bromide
Tag:Prilocaine(721-50-6) Related Product Information
Propionamide MIXTUREOFAMYLOCAINE,LIGNOCAINE,PRILOCAINE PRILOCAINE HYDROCHLORIDE IMP. B (EP): 2-METHYLBENZENAMINE (O-TOLUIDINE) PRILOCAINE HCL USP(CRM STANDARD) PRILOCAINE IMPURITY E(RS)-N-(METHYLPHENYL)-2-(PROPYLAMINO)PROPANAMIDE EPP(CRM STANDARD) prilocaine-phenylephrine PRILOCAINE RELATED COMPOUND B (50 MG) ((RS)-N-(4-METHYLPHENYL)-2-(PROPYLAMINO)PROPANA-MIDE) PRILOCAINE IMPURITY E (R)-Prilocaine,D-(-)-Prilocaine (S)-Prilocaine,L-(+)-Prilocaine Prilocaine Isopropylamine (-)-2-[METHYLAMINO]-1-PHENYLPROPANE Prilocaine HCL //Prilocaine,PRILOCAINE HCL,PRILOCAINE HYDROCHLORIDE,PRILOCAINE HYDROCHLORIDE USP,PRILOCAINE HYDROCHLORIDE BP STANDARD,PRILOCAINE HYDROCHLORIDE MM,PRILOCAINE HYDROCHLORIDE ASSAY STANDARD BP(CRM STANDARD),PRILOCAINE HYDROCHLORIDE BP STANDARD(CRM STANDARD),PRILOCAINE HYDROCHLORIDE EPP(CRM STANDARD),PRILOCAINE HYDROCHLORIDE EPP,PRILOCAINE HYDROCHLORIDE MM(CRM STANDARD) Allylamine D/L-AMPHETAMINE HYDROCHLORIDE Propylamine