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Bortezomib

Bortezomib Suppliers list
Company Name:Nanjing Norris-Pharm Technology Co., Ltd  Gold
Tel:+86-25-66112881 +86-25-66112885
Email:sales@norris-pharm.com
Company Name:Beijing Zhongshuo Pharmaceutical Technology Development Co., Ltd  Gold
Tel:010-64430626/13801208576
Email:maggie@chinazhongshuo.com
Company Name:Wuhan Biocar Bio-Pharm Co., Ltd.  Gold
Tel:15327198583
Email:newbio@biocar.cn
Company Name:Mascot I.E. Co., Ltd  Gold
Tel:+86-519-85010339/362/319
Email:info@mascot-ie.com
Company Name:Ningbo EST Chemical Co., Ltd  Gold
Tel:+86 (574) 8737-1832
Email:est@estchemical.com
Bortezomib Basic information
Drug for Cancer treatment
Product Name:Bortezomib
Synonyms:VELCADE;dpba;BORTEZOMIB;[(1r)-3-methyl-1-[[(2s)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]-boronic acid;VELCADE(BORTEZOMIB);Boronic acid, B-[(1R)-3-methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]-;Bortezomib for research;Bortezomib ( Velcade, MG-341, PS-341 )
CAS:179324-69-7
MF:C19H25BN4O4
MW:384.24
EINECS:
Product Categories:Boron Derivatives;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Pepetides;ProteasomeInhibitors;Apis;Inhibitor;Final material;API;peptides
Mol File:179324-69-7.mol
Bortezomib Structure
Bortezomib Chemical Properties
mp 122-124°C
density 1.214
storage temp. Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Stability:Hygroscopic and Moisture Sensitive
CAS DataBase Reference179324-69-7(CAS DataBase Reference)
Safety Information
Hazardous Substances Data179324-69-7(Hazardous Substances Data)
MSDS Information
Bortezomib Usage And Synthesis
Drug for Cancer treatmentBortezomib is a drug for treatment of hematopoietic malignancies with the appearance being white or white-like crystalline powder. It is easily soluble in dimethyl sulfoxide, ethanol, but insoluble in aqueous solution. This product is the reversible inhibitor of the mammal cell 26S proteasome chymotrypsin-like activity. 26S proteasome is a large protein complex which can degrade ubiquitin. Ubiquitin proteasome pathway plays an important role in regulation of the intracellular concentration of specific proteins in order to maintain the stability of the intracellular environment. Proteolytic affects intracellular multi-level signalling cascade. The disruption of the normal intracellular environment can lead to cell death while the inhibition of the 26S proteasome can prevent the hydrolysis of specific proteins. In vitro tests have proved bortezomib exhibits cytotoxicity to multiple types of cancer cells. The in vivo models of preclinical tumor have proved that bortezomib is capable of delaying the tumor growth of multiple myeloma which is suitable for the treatment of multiple myeloma.
The above information is edited by the Chemicalbook of Dai Xiongfeng.
Chemical PropertiesYellow Solid
UsageBortezomib is the first proteasome inhibitor to be approved b the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. T
UsageBortezomib is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle foun d in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.
Usageselective proteasome inhibitor
Bortezomib Preparation Products And Raw materials
Tag:Bortezomib(179324-69-7) Related Product Information
Bortezomib Bensulfuron methyl tert-Butylchlorodiphenylsilane EC 2.6.1.2 (4R)-4-[[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]methyl]oxazolidin-2-one Propyl butyrate 3,4'-DIAMINODIPHENYLMETHANE Methyl salicylate Propyl gallate Methyl Kresoxim-methyl Thiophanate-methyl Glucosamine Phenylacetone ACETAMINOPHENOL BP/USP Methyl bromide Isopropanol PHENYL VALERATE