- Ipratropium Bromide
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- $0.00 / 1KG
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2023-11-27
- CAS:66985-17-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20 TONS
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| | Ipratropium bromide monohydrate Basic information |
| Product Name: | Ipratropium bromide monohydrate | | Synonyms: | Unii-J697uz2A9j;Ipratropium Bromide (100 mg);3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2.1)octane bromide monohydrate;8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl;IPRATROPIUM BROMIDE MONOHYDRATE;Ipratropium bromide CRS;IpratropiumBromideMonohydrate>;Ipratropium Bromider | | CAS: | 66985-17-9 | | MF: | C20H32BrNO4 | | MW: | 430.38 | | EINECS: | 622-130-2 | | Product Categories: | VASOTEC | | Mol File: | 66985-17-9.mol |  |
| | Ipratropium bromide monohydrate Chemical Properties |
| Melting point | 231 °C | | storage temp. | 2-8°C | | solubility | H2O: soluble10mg/mL | | form | powder | | color | white | | Stability: | Hygroscopic | | InChIKey | KEWHKYJURDBRMN-XSAPEOHZNA-M | | SMILES | C([N+]1([C@@H]2C[C@@H](OC(=O)C(C3C=CC=CC=3)CO)C[C@H]1CC2)C)(C)C.[Br-].O |&1:2,4,18,r| |
| Hazard Codes | Xn | | Risk Statements | 20/22-36 | | Safety Statements | 26 | | RTECS | YM3700000 | | HS Code | 2939800000 |
| | Ipratropium bromide monohydrate Usage And Synthesis |
| Description | Ipratropium bromide is a quaternary ammonium congener of atropine and is an anticholinergic compound approved for use as a bronchodilator. Anticholinergic agents produce bronchodilatation by antagonizing the activity of acetylcholine at the level of its receptor, particularly those found on airway smooth muscle in the large, central airways. The onset of action of ipratropium is relatively slow (20 minutes), and the peak effect occurs at 60 minutes.1 Ipratropium, unlike atropine, is poorly absorbed across mucous membranes and has little toxicity at the usual doses. | | Chemical Properties | White or almost white, crystalline powder. | | Uses | antihypertensive | | Uses | Ipratropium bromide monohydrate has been used for the inhibition of peripheral muscarinic receptors in rats. | | Definition | ChEBI: The monohydrate form of ipratropium bromide. An anticholinergic drug, ipratropium bromide blocks the muscarinic cholinergic receptors in the smooth muscles of the bronchi in the lungs. This opens the bronchi, so providing relief in chronic obstructive pulm
nary disease and acute asthma. | | Brand name | Atrovent (Boehringer Ingelheim). | | Biochem/physiol Actions | Ipratropium bromide monohydrate is a nonselective muscarinic acetylcholine receptor antagonist and a bronchodilator. In nebulized form, it is used for treating asthma and obstructive pulmonary diseases. It acts as a β2 adrenoreceptor agonist. Ipratropium bromide monohydrate is an anticholinergic agent and competes with acetylcholine. It promotes bronchodilation by stimulating sympathetic pathways. | | Clinical Use | Anticholinergic bronchodilator:
Reversible airways obstruction, particularly in
COPD | | Side effects | Previous severe allergic reaction symptoms upon using ipratropium or atropine and its other derivatives, such as angioedema, urticaria, severe shortness of breath, oropharyngeal edema, and ultimately anaphylaxis is a contraindication to ipratropium use.
Ipratropium aerosols can cause bronchospasms (paradoxical), which usually happens upon the initial use of this medication | | Metabolism | After inhalation, around 10-30% of a dose is deposited
in the lungs where it exerts its therapeutic effect. Only
a small amount of ipratropium reaches the systemic
circulation. The majority of a dose is swallowed but
is poorly absorbed from the gastrointestinal tract.
Ipratropium and its metabolites are eliminated in the
urine and faeces. |
| | Ipratropium bromide monohydrate Preparation Products And Raw materials |
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