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Methanol

Methanol Suppliers list
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
Tel: 0755-23311925 18102838259
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Products Intro: Product Name:Methanol
CAS:67-56-1
Purity:99% Package:3.6/KG
Company Name: Shanghai Bojing Chemical Co.,Ltd.
Tel: +86-21-37122233
Email: Candy@bj-chem.com
Products Intro: Product Name:Methanol
CAS:67-56-1
Purity:99% Package:1kg;25kg;200kg Plastic drum Remarks:Colorless liquid
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:67-56-1
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: J & K SCIENTIFIC LTD.  Gold
Tel:400-666-7788 +86-10-82848833
Email:jkinfo@jkchemical.com;market6@jkchemical.com
Products Intro:Product Name:Methanol, for synthesis
CAS:67-56-1
Purity:99.8% Package:1L,500ML
Company Name: Spectrum Chemical Manufacturing Corp.  Gold
Tel:021-67601398,18616765336,QQ:3475911745
Email:mkt@spectrumchina.net
Products Intro:Product Name:Methyl Alcohol
CAS:67-56-1
Purity:SpectrophotoMetric Grade, ACS Package:1LT Remarks:SP161
Methanol Basic information
Introduction Uses Methanol poisoning and First Aid Measures Production Toxicity Methanol gasoline
Product Name:Methanol
Synonyms:METHYL RED MIXED SOLUTION;METHYL RED, NEUTRAL;METHYL RED MIXED SOLUTION R;METHYL RED INDICATOR;METHYL RED ETHANOL;METHYL RED, WATER SOLUBLE;METHYL RED, SPIRIT SOLUBLE;METHYL RED SOLUTION R
CAS:67-56-1
MF:CH4O
MW:32.04
EINECS:200-659-6
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Mol File:67-56-1.mol
Methanol Structure
Methanol Chemical Properties
Melting point -98 °C(lit.)
Boiling point 65.4 °C(lit.)
density 0.791 g/mL at 25 °C
vapor density 1.11 (vs air)
vapor pressure 410 mm Hg ( 50 °C)
refractive index n20/D 1.329(lit.)
Fp 52 °F
storage temp. Store at RT.
solubility benzene: miscible(lit.)
pka15.2(at 25℃)
form Liquid Free From Particulates
color <10(APHA)
Relative polarity0.762
explosive limit5.5-44%(V)
Water Solubility miscible
Merck 14,5957
BRN 1098229
CAS DataBase Reference67-56-1(CAS DataBase Reference)
NIST Chemistry ReferenceMethyl alcohol(67-56-1)
EPA Substance Registry SystemMethanol(67-56-1)
Safety Information
Hazard Codes Xn,T,F
Risk Statements 10-20/21/22-68/20/21/22-39/23/24/25-23/24/25-11-40-36-36/38-23/25
Safety Statements 36/37-7-45-16-24/25-23-24-26
RIDADR UN 1170 3/PG 2
WGK Germany 1
RTECS PC1400000
3-10
TSCA Yes
HazardClass 3
PackingGroup II
Hazardous Substances Data67-56-1(Hazardous Substances Data)
MSDS Information
ProviderLanguage
Carbinol English
SigmaAldrich English
ACROS English
ALFA English
Methanol Usage And Synthesis
IntroductionMethanol is the simplest fatty alcohol. It is a colorless, flammable, irritating liquid with a boiling point of 64.7°C, a melting point of -93.90°C, and a relative density of 0.7913. Soluble in water and most organic solvents. Its severe toxicity can damage the optic nerve. Once swallowed, it can make the eyes blind and even cause death.
Methanol has the general properties of a primary aliphatic alcohol. The three hydrogen atoms on a carbon atom with a hydroxyl group can be oxidized, orderly generating formaldehyde, formic acid, and carbon dioxide. Therefore, it is largely used in the synthesis of formaldehyde. Methanol is easily converted into important organic synthesis intermediates such as methyl carboxylate, methyl chloride and methylamine, and it is also applied as important organic solvents, extraction agents and alcohol denaturants.
UsesMethanol is an important chemical raw material for fine chemicals. Its carbonylation at 3.5 MPa and 180-200° C in the presence of catalyst can produce acetic acid and further produce acetic anhydride. It reacts with syngas to prepare vinyl acetate in the presence of catalyst; reacts with isobutylene to produce tert-butyl methyl ether; prepare dimethyl oxalate through oxidization and carbonylation, and a further hydrogenation to produce ethylene glycol; reacts with toluene under catalyst and simultaneous oxidization to produce phenylethyl alcohol. It can be used as a good solvent, as a pesticide raw material, as an antifreeze agent, as a fuel and fuel additive (this is receiving increasing attention in environmental protection field). It is the main raw material in the preparation of formaldehyde, the raw material in medicine and spices production, a solvent in dyes and paint industries, the raw material in preparation of methanol single cell protein and synthesis of methyl ester.
Industry Applications Role/Benefit
Laboratory HPLC, UV/VIS spectroscopy, and LCMS Low UV cutoff
Chemical manufacture Production of formaldehyde and its derivates Main feedstock
Production of hydrocarbon chains and even aromatic systems Main feedstock
Production of methyl tert-butyl ether Methylation reagent
Production of dimethyl terephthalic acid, methyl methacrylate and acrylic acid methyl ester Main feedstock
Plastics Production of polymers Main feedstock
Farm chemical Production of insecticide and acaricide Main feedstock
Pharmaceuticals Production of sulfonamides, amycin, etc Main feedstock
Fuel for vehicles Pure methanol fuel Pure methanol does not produce an opaque cloud of smoke in the event of an accident
Methanol gasoline Blended directly into gasoline to produce a high-octane, efficient fuel with lower emissions than conventional gasoline
Chemical analysis Determination of boron Analysis agent
Determination of trace moisture in alcohols, saturated hydrocarbons, benzene, chloroform, pyridine Analysis agent
Others Separation of calcium sulfate and magnesium sulfate Separation reagent
Separation of strontium bromide and barium bromide Separation reagent
Anti-freezing agent Effective component
Methanol poisoning and First Aid MeasuresPathogenesis
First, methanol has a cumulative effect and is oxidized in the body into more toxic formaldehyde and formic acid. Methanol and its oxides directly damage the tissues, causing cerebral edema, meningeal hemorrhage, optic nerve and retinal atrophy, pulmonary congestion and edema, and hepatic and renal turbid swelling.
Second, methanol and its oxides cause blood circulation disorder, coenzyme system obstacles in vivo, resulting in lack of oxygen supply to the brain cortical cells, metabolic disorders, and related neurological and psychiatric symptoms.
Third, methanol oxidation products combine with the iron in the cytochrome oxidase, which inhibits the intracellular oxidation process thus causing metabolic disorders, acidosis along with organic acid accumulation in the body, and nerve cells impair.

Treatment
  • Keep away from the methanol dispersion area, excrete methanol from the body.
    Antidote: Ethanol is an antidote to methanol poisoning. Ethanol can prevent methanol’s oxidation and promote its emission. Prepare 5% ethanol solution using 10% glucose solution, and drip slowly intravenously.
  • Maintain electrolyte balance: maintain respiratory and circulatory function, provide with a large number of Vitamin B.
    Treatment of acidosis: Administrate timely sodium bicarbonate solution or sodium lactate solution based on blood gas analysis, carbon dioxide binding force measurement and clinical performance.
  • Prevent cerebral edemas actively, reduce intracranial pressure, improve fundus blood circulation, and prevent optic neuropathy if needed.
  • Inject intravenously cytochrome C, polar fluid to restore cytochrome oxidase function.
  • Control mental state by applying diazepam, perphenazine and the like.
Symptoms and treatments:
Acute pain morphine, pethidine
Convulsions phenobarbital, amimystrine, diazepam
Coma caffeine sodium benzoate
Respiratory failure nikethamide, theophylline
Production
  • Methanol is prepared by pressure heating with carbon monoxide and hydrogen in the presence of a catalyst:
   
If the conditions are strictly controlled, the yield can reach 100% and the purity can reach 99%.
  • Methane is mixed with oxygen (9:1, V/V) and methanol is obtained through a copper tube under heating and pressure:
ToxicityADI is limited to GMP (FAO/WHO, 2001).
Toxic, can cause blindness.
LD50: 5628 mg/kg (rat, oral).
 
Measurement Date System Route/Organism Dose Effect
Skin and Eye Irritation December 2016   eye /rabbit 40 mg moderate
Skin and Eye Irritation December 2016   eye /rabbit 100 mg/24H moderate
Skin and Eye Irritation December 2016   skin /rabbit 20 mg/24H moderate
Mutation Data December 2016 Cytogenetic Analysis parenteral/grasshopper 3000 ppm  
Mutation Data December 2016 Cytogenetic Analysis oral/mouse 1 gm/kg  
Mutation Data December 2016 Cytogenetic Analysis intraperitoneal/mouse 75 mg/kg  
Mutation Data December 2016 DNA Damage oral/rat 10 µmol/kg  
Mutation Data December 2016 DNA inhibition lymphocyte/human 300 mmol/L  
Mutation Data December 2016 DNA repair /Escherichia coli 20 mg/well  
Mutation Data December 2016 morphological transform fibroblast/mouse 0.01 mg/L/21D (-enzymatic activation step)  
from The National Institute for Occupational Safety and Health - NIOSH
Methanol gasolineMethanol gasoline refers to the M series mixture fuel made of addition of methanol to the gasoline and formulated using methanol fuel solvent. Among them, M15 (add 15% methanol in gasoline) clean methanol gasoline is used as vehicle fuel, respectively, used in a variety of gasoline engines. It can be applied to substitute the finished gasoline without changing the existing engine structure, and can also be mixed with refined oil. The methanol mixed fuel has excellent thermal efficiency, power, start-up and being economical. It is also characterized by lowering the emissions, saving oil and being safe and convenient. Methanol gasoline types of M35, M15, M20, M50, N85 and M100 with different blend ratios have been developed around the world according to the conditions of different countries. At present, the commercial methanol is mainly M85 (85% methanol + 15% gasoline) and M100 with M100 performance being better than M85 and having greater environmental advantages.
UsesMeets ACS specifications
UsesSuitable for HPLC, spectrophotometry, and some LC-MS applications
Useshigh purity grade for ICP-MS detection
UsesSuitable for volatile organics analysis by GC-MS
DefinitionChEBI: The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.
UsesIndustrial solvent. Raw material for making formaldehyde and methyl esters of organic and inorganic acids. Antifreeze for automotive radiators and air brakes; ingredient of gasoline and diesel oil antifreezes. Octane booster in gasoline. As fuel for picnic stoves and soldering torches. Extractant for animal and vegetable oils. To denature ethanol. Softening agent for pyroxylin plastics. Solvent and solvent adjuvant for polymers. Solvent in the manufacture of cholesterol, streptomycin, vitamins, hormones, and other pharmaceuticals.
General DescriptionA colorless fairly volatile liquid with a faintly sweet pungent odor like that of ethyl alcohol. Completely mixes with water. The vapors are slightly heavier than air and may travel some distance to a source of ignition and flash back. Any accumulation of vapors in confined spaces, such as buildings or sewers, may explode if ignited. Used to make chemicals, to remove water from automotive and aviation fuels, as a solvent for paints and plastics, and as an ingredient in a wide variety of products.
Reactivity ProfileMethanol reacts violently with acetyl bromide [Merck 11th ed. 1989]. Mixtures with concentrated sulfuric acid and concentrated hydrogen peroxide can cause explosions. Reacts with hypochlorous acid either in water solution or mixed water/carbon tetrachloride solution to give methyl hypochlorite, which decomposes in the cold and may explode on exposure to sunlight or heat. Gives the same product with chlorine. Can react explosively with isocyanates under basic conditions. The presence of an inert solvent mitigates this reaction [Wischmeyer 1969]. A violent exothermic reaction occurred between methyl alcohol and bromine in a mixing cylinder [MCA Case History 1863. 1972]. A flask of anhydrous lead perchlorate dissolved in Methanol exploded when Methanol was disturbed [J. Am. Chem. Soc. 52:2391. 1930]. P4O6 reacts violently with Methanol. (Thorpe, T. E. et al., J. Chem. Soc., 1890, 57, 569-573). Ethanol or Methanol can ignite on contact with a platinum-black catalyst. (Urben 1794).
Health HazardExposure to excessive vapor causes eye irritation, head- ache, fatigue and drowsiness. High concentrations can produce central nervous system depression and optic nerve damage. 50,000 ppm will probably cause death in 1 to 2 hrs. Can be absorbed through skin. Swallowing may cause death or eye damage.
Fire HazardBehavior in Fire: Containers may explode.
Methanol Preparation Products And Raw materials
Raw materialsSodium hydroxide-->Hydrogen-->CARBON DIOXIDE-->Oxygen-->CARBON MONOXIDE-->tert-Butyl methyl ether-->Lactic acid -->METALLURGICAL COKE--> HEAVY CUT RESIDUE OIL-->METHANE-->2 DIESEL FUEL-->Residuum-->L(+)-Lactic acid
Preparation ProductsH-DL-PRO-OME HCL-->2-Amino-4-methoxypyridine-->1,5-NAPHTHALENEDISULFONIC ACID DISODIUM SALT, DIHYDRATE, 98-->3,5-Dimethoxybenzyl alcohol-->METHYL 3-AMINOBENZOATE-->3-Methacryloxypropyltrimethoxysilane-->3'-DIMETHYLAMINOACETOPHENONE-->5-METHYL-2-HEXANOL-->TETRAHYDRO-3-FUROIC ACID-->2-Quinolinemethanamine-->NICOTINIC ACID HYDRAZIDE-->5-Bromo-4,6-dihydroxypyrimidine-->1-(1,3-DIHYDRO-1-OXOISOBENZOFURAN-3-YL)UREA-->(1H-IMIDAZOL-2-YL)-METHANOL-->2-OXO-6-PHENYL-4-(TRIFLUOROMETHYL)-1,2-DIHYDRO-3-PYRIDINECARBONITRILE-->Ethyl 3-(benzylamino)propanoate-->METHYL TRICOSANOATE-->5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE-->Methyl 4-aminobutyrate hydrochloride-->N,N'-BISBENZYLIDENEBENZIDINE-->4-Hydroxy-5-fluorpyrimidine-->TRIETHYLENE GLYCOL MONOMETHYL ETHER-->1-Chloropinacolone-->Dipropylene glycol monomethyl ether-->3-(METHOXYCARBONYL)PYRIDINE-2-CARBOXYLIC ACID-->4-(METHOXYCARBONYL)NICOTINIC ACID-->Methyl 3,4-dimethylbenzoate-->4-Bromobenzyl alcohol-->4-MORPHOLINECARBOXAMIDINE-->2-Thiophenecarboxylic acid hydrazide-->METHYL HYDROGEN GLUTARATE-->METHYL STEARATE-->2-Methoxy-3-isobutyl pyrazine-->Diphenyldimethoxysilane-->methylated albumin-->FEMA 2062-->3-Chloropropyltrimethoxysilane-->3-Glycidoxypropyltrimethoxysilane-->Vinyltrimethoxysilane-->Potassium methoxide
Tag:Methanol(67-56-1) Related Product Information
Acetic acid glacial Acetonitrile Toluene METHYL ISOCYANOACETATE SALCOMINE Aluminum acetylacetonate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Cupric acetylacetonate Methanol Methyl bromide Methyl Kresoxim-methyl Sodium methanolate Methylparaben Bensulfuron methyl Methyl cellulose Methyl acrylate 2-[[[[(4-Methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]amino]sulfonyl]benzoic acid methyl ester