ChemicalBook CAS DataBase List (2E)-1-(4-bromophenyl)-3-phenylprop-2-en-1-one

(2E)-1-(4-bromophenyl)-3-phenylprop-2-en-1-one synthesis

12synthesis methods

Product Name:(2E)-1-(4-bromophenyl)-3-phenylprop-2-en-1-one
CAS Number:2403-27-2
Molecular formula:C15H11BrO
Molecular Weight:287.15

108-86-1 Synthesis

108-86-1
494 suppliers
$10.00/5g

102-92-1
273 suppliers
$6.00/25g

(2E)-1-(4-bromophenyl)-3-phenylprop-2-en-1-one

2403-27-2
16 suppliers
$116.64/1gm:

Yield: 86%

Reaction Conditions:

with zinc(II) oxide at 25 - 30; for 2 h;regioselective reaction;Friedel-Crafts Acylation;

Steps:

General procedure: A mixture of α,β-unsaturated acid chloride (501 mg, 3 mmol), an aromatic compound (324 mg, 3 mmol) and zinc oxide (120 mg, 1.5 mmol) was stirred at room temperature (25-30 °C) for the specified time (Table 2). The progress of the reaction was monitored by TLC. After completion of the reaction, the product was extracted with dichloromethane (3 × 5 mL), and extract was washed with aq. NaHCO₃. The organic layer was dried over anhydrous Na₂SO₄ and removal of the solvent under reduced pressure furnished analytically pure product with 92% yield (219 mg).

References:

More, Parmeshwar E.;Bandgar, Babasaheb P.;Kamble, Vinod T. [Catalysis Communications,2012,vol. 27,p. 30 - 32]