ChemicalBook CAS DataBase List 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one synthesis

8synthesis methods

Product Name:3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
CAS Number:881386-01-2
Molecular formula:C11H10Cl2N2O3
Molecular Weight:289.11

38560-30-4 Synthesis

38560-30-4
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3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one

881386-01-2
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Yield:881386-01-2 94.9%

Reaction Conditions:

with phosphorus(V) chloride in chlorobenzene at 55; for 5 h;

Steps:

1 Synthesis of 3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one

Compound II (40 g, 0.18 mol) was added to a 1000 mL eggplant-Chlorobenzene (400 ml),Phosphorus pentachloride (132.4 g, 0.64 mol) was added portionwise with stirring,After the addition warmed to 55 reaction 5h.The reaction solution was cooled to room temperature,Poured into 1000mL ice water,Separate the lower, and then extracted with dichloromethane 3 × 200mL,The combined organic phases were washed twice with 2 × 200 mL of water,400mL saturated brine was washed once,Dried over anhydrous sodium sulfate,Dichloromethane evaporated to give the product,Light yellow solid, 49.4 g, m.p.115-117°C, Yield 94.9%.

References:

CN107400131,2017,A Location in patent:Paragraph 0026; 0031; 0036-0038

1575-61-7 Synthesis