3-CHLORO-4'-FLUOROPROPIOPHENONE synthesis
- Product Name:3-CHLORO-4'-FLUOROPROPIOPHENONE
- CAS Number:347-93-3
- Molecular formula:C9H8ClFO
- Molecular Weight:186.61
625-36-5
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$45.00/100ml
460-00-4
602 suppliers
$6.00/10g
347-93-3
175 suppliers
$8.00/5g
Yield:-
Reaction Conditions:
Stage #1:1-Bromo-4-fluorobenzene with magnesium in tetrahydrofuranInert atmosphere;Heating;
Stage #2:2-chloropropionyl chloride in tetrahydrofuran at 0; for 3 h;Inert atmosphere;
Steps:
4,7-Bis-(4-fluorophenyl)-1,10-phenanthroline(1)
4,7-Bis-(4-fluorophenyl)-1,10-phenanthroline(1): (1) To an oven dried 500 mL three neck flask equipped with stir bar, condenser, and argon inlet was added 20,000 g of 4-fluorobromobenzene (0.115 mol) and 200 mL of freshly distilled tetrahydrofuran. 5.555 g (0.230 mol) of freshly cleaned magnesium turnings was added while under argon flow. The solution was gently heated until the color changed to brown and visually half of the magnesium was consumed. The resulting Grignard was then canulated to a flask equipped with stir bar and argon inlet, containing 14.982 g (0.118 mol) 3-chloropropionic acid chloride at in 100 mL of freshly distilled tetrahydrofuran maintained at a temperature of 0 °C on an ice bath. The Grignard was added over a period of 90 min and stirred for 90 min after addition. The solvents were then removed by rotary evaporation and the remaining solids were flash chromatographed using methylene chloride and silica. The resulting 3-chloro-1-(4-fluoro-phenyl)-propan-1-one was used without further purification.
References:
Carlson, Brenden;Flowers, Sarah;Kaminsky, Werner;Phelan, Gregory D. [Journal of Fluorine Chemistry,2015,vol. 173,p. 63 - 68]
462-06-6
414 suppliers
$10.00/5g
625-36-5
352 suppliers
$45.00/100ml
347-93-3
175 suppliers
$8.00/5g