ChemicalBook CAS DataBase List 3-Chlorophenol

3-Chlorophenol synthesis

14synthesis methods

Product Name:3-Chlorophenol
CAS Number:108-43-0
Molecular formula:C6H5ClO
Molecular Weight:128.56

24318-02-3 Synthesis

24318-02-3
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108-43-0
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Yield:108-43-0 99%

Reaction Conditions:

with 1-n-butyl-3-methylimidazolim bromide at 200 - 220; for 0.0833333 h;Microwave irradiation;Inert atmosphere;

Steps:

2. Preparation of phenolic compounds

General procedure: To a microwave tube was added alkyl aryl ether (1.0 mmol) and 1-n-butyl-3-methylimidazolium bromide (0.65 g, 3.0 mmol). The reaction tube was flushed with argon and then was irradiated at 20 W for the designated time period with air-flow cooling to prevent overheating (power control mode). After cooled to room temperature, the reaction mixture was acidified with 1 NHCl solution and extracted with ethyl acetate (3 × 15 mL). The combined organic layer was washed with water and brine, and dried over anhydrous MgSO₄ and the solvent was evaporated under vacuum. Purification of the crude product by column chromatography (ethyl acetate in n-hexane)afforded the desired product.

References:

Park, Se Kyung;Battsengel, Oyunsaikhan;Chae, Junghyun [Bulletin of the Korean Chemical Society,2013,vol. 34,# 1,p. 174 - 178] Location in patent:supporting information

625-99-0 Synthesis