Pyrazolo[1,5-a]pyridine-3-carboxylic acid, 2-Methyl-, ethyl ester synthesis
- Product Name:Pyrazolo[1,5-a]pyridine-3-carboxylic acid, 2-Methyl-, ethyl ester
- CAS Number:30843-10-8
- Molecular formula:C11H12N2O2
- Molecular Weight:204.23
Yield:30843-10-8 70%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20; for 72 h;
Steps:
31.1 Step 1
Example 31 Synthesis of tert-Butyl(2-methylpyrazolo[1,5-a]pyridin-3-yl)carbamate (CE298) Step 1: 1-Aminopyridinium iodide (10 g), ethyl but-2-ynoate (6.05 g), potassium carbonate (7.45 g) were mixed in anhydrous DMF (50 mL). The reaction mixture was stirred at ambient temperature for 3 days. A mixture of water (100 mL), ethyl acetate (100 mL) and hexane (100 mL) was added and the product was collected by filtration. The filter cake was washed with a mixture of ethyl acetate:hexane=1:1, affording 6.4 g of ethyl 2-methylpyrazolo[1,5-a]pyridine-3-carboxylate (70% yield).
References:
US2015/246923,2015,A1 Location in patent:Paragraph 0480-0481
