ChemicalBook CAS DataBase List 4,4'-Dibromobenzophenone

4,4'-Dibromobenzophenone synthesis

11synthesis methods

Product Name:4,4'-Dibromobenzophenone
CAS Number:3988-03-2
Molecular formula:C13H8Br2O
Molecular Weight:340.01

108-86-1 Synthesis

108-86-1
493 suppliers
$10.00/5g

586-75-4
217 suppliers
$10.00/5g

3988-03-2
213 suppliers
$6.00/1g

Yield:3988-03-2 83%

Reaction Conditions:

Stage #1:bromobenzene;4-chlorobenzoyl chloride with aluminum (III) chloride at 55; for 72 h;Inert atmosphere;
Stage #2: with hydrogenchloride in waterInert atmosphere;Cooling with ice;

Steps:

2.2.2 Bis(4-bromophenyl)methanone (1)
A mixture of 4-bromobenzoyl chloride (6.58g, 30mmol) in bromobenzene (25mL) was added at a solution of AlCl₃ (4g, 30mmol) in bromobenzene (26mL) under nitrogen. The mixture was stirred at 55°C for 3 days and then, 100g ice and 50mL HCl conc. were added. The resulting mixture was extracted twice with diethyl ether, washed with aqueous NaOH 5% and then with water, dried over magnesium sulfate, then concentrated under vacuum. The crude product recrystallized from methanol gave white powder (8.45g, 83%).

References:

Erko, Firealem G.;Cseh, Liliana;Berthet, Jérôme;Mehl, Georg H.;Delbaere, Stéphanie [Dyes and Pigments,2015,vol. 115,p. 102 - 109]

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